Gene: TPI1

official authority: TPI1, triosephosphate isomerase 1

• Synonyms: MGC88108; TPI
• Other Designations: -
• Description: triosephosphate isomerase 1
• Type: protein-coding
• Chromosome: 12
• Organism: Homo sapiens
• Omim: 190450
  
• title:Triosephosphate isomerase 1;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; tonsil; trachea; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA microarray	---	11823860
Down	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA microarray	---	11823860
Up	---	F	---	Grade 1(2) vs 3	---	cDNA microarray	---	11823860

• Protein Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	5	F	---	ErbB2 positive vs negative	---	Matrix-assisted laser desorption and ionization-time of flight mass spectrometry Two dimensional Western Blot	---	16048908

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000012.11	NM_000365.5	NP_000356.1	P60174	1HTI 1WYI 2IAM 2IAN 2JK2 2VOM

Gene Expression Data

• genes highly correlated to TPI1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: TPIS_HUMAN

• Description: AltName: Full=Triose-phosphate isomerase;
• Length: 249 aa
• Function:
• Location:

InterPro domains

• Aldolase-type TIM barrel (IPR013785)
• Triosephosphate isomerase (IPR000652)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Glycolysis / Gluconeogenesis (KEGG map) (KEGG ontology)
• Fructose and mannose metabolism (KEGG map) (KEGG ontology)
• Inositol phosphate metabolism (KEGG map) (KEGG ontology)
• Metabolic pathways (KEGG map) (KEGG ontology)

• Diabetes pathways (Reactome)

• Integration of energy metabolism (Reactome)

• Metabolism of carbohydrates (Reactome)

Gene Ontology

• Functions
  • triose-phosphate isomerase activity (GO:0004807)
  • triose-phosphate isomerase activity (GO:0004807)
  • triose-phosphate isomerase activity (GO:0004807)
  • isomerase activity (GO:0016853)
• Processes
  • gluconeogenesis (GO:0006094)
  • glycolysis (GO:0006096)
  • pentose-phosphate shunt (GO:0006098)
  • fatty acid biosynthetic process (GO:0006633)
  • metabolic process (GO:0008152)
  • embryonic development (GO:0009790)
  • glyceraldehyde-3-phosphate metabolic process (GO:0019682)
• Components
  • cytosol (GO:0005829)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
TPI1	TPI1	Invitro	Mainfroid V et al.	8609635
TPI1	CFL1	Invivo	Jung J et al.	12359716
TPI1	TPI1	Affinity Capture-MS	Rual JF et al.	16189514
CFL1	TPI1	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources