Gene: MLLT10

official authority: MLLT10, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

• Synonyms: AF10; DKFZp686E10210; MGC75086
• Other Designations: ALL-1 fused gene from chromosome 10; OTTHUMP00000019275; OTTHUMP00000045273; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 10; myeloid/lymphoid or mixed-lineage leukemia translocated to, 10; type I AF10 protein
• Description: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
• Type: protein-coding
• Chromosome: 10
• Organism: Homo sapiens
• Omim: 602409
  
• title:Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10;
• tissue expression: adrenal gland; ascites; bladder; blood; bone; brain; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; pharynx; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; trachea; uterus; vascular; breast (mammary gland) tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA microarray	---	11823860
Down	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA microarray	---	11823860
Up	---	F	---	Grade 1(2) vs 3	---	cDNA microarray	---	11823860
Up	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000010.10	NM_001009569.1	NP_001009569.1	P55197	---
NC_000010.10	NM_004641.2	NP_004632.1	P55197	---

Gene Expression Data

• genes highly correlated to MLLT10 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: AF10_HUMAN

• Description: RecName: Full=Protein AF-10;
• Length: 1027 aa
• Function:
• Location: Nucleus (Potential).

InterPro domains

• Zinc finger, PHD-type, conserved site (IPR019786)
• Zinc finger, PHD-type (IPR001965)
• Zinc finger, PHD-finger (IPR019787)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • transcription factor activity (GO:0003700)
  • protein binding (GO:0005515)
  • zinc ion binding (GO:0008270)
  • metal ion binding (GO:0046872)
• Components
  • nucleus (GO:0005634)
  • cytoplasm (GO:0005737)

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Note: data printed here are integrated from public resources