Gene: PPM1D

official authority: PPM1D, protein phosphatase 1D magnesium-dependent, delta isoform

• Synonyms: PP2C-DELTA; WIP1
• Other Designations: p53-induced protein phosphatase 1; protein phosphatase 1D; protein phosphatase 2C delta isoform; protein phosphatase Wip1
• Description: protein phosphatase 1D magnesium-dependent, delta isoform
• Type: protein-coding
• Chromosome: 17
• Organism: Homo sapiens
• Omim: 605100
  
• title:Protein phosphatase 1D magnesium-dependent, delta isoform;
• tissue expression: ascites; blood; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph node; mammary gland; mouth; ovary; pancreas; placenta; skin; spleen; stomach; testis; thymus; thyroid; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; head and neck tumor; kidney tumor; leukemia; lung tumor; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; retinoblastoma; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• DNA Amplification - Cell Line data

Type	Contig number	Fold	Cell line	Methods	Link to Pubmed
Amplification	---	4	BT474 - Human	Polymerase Chain Reaction	12021784
Amplification	---	11	MCF7 - Human	Polymerase Chain Reaction	12021784
Amplification	---	2	BT747 - Human	Northern blot	12021785
Amplification	---	2	MCF7 - Human	Northern blot	12021785

• Protein Expression - Cell Line data

Expression	Fold	Cell line	Methods	Link to Pubmed
Up	19	BT20 - Human MDAMB134 - Human MDAMB175 - Human vs BT474 - Human	Western blot	12021784
Up	66	BT20 - Human MDAMB134 - Human MDAMB175 - Human vs MCF7 - Human	Western blot	12021784

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000017.10	NM_003620.2	NP_003611.1	O15297	---

Gene Expression Data

• genes highly correlated to PPM1D in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: PPM1D_HUMAN

• Description: AltName: Full=Protein phosphatase magnesium-dependent 1 delta;
• Length: 605 aa
• Function: Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
• Location:

InterPro domains

• Protein phosphatase 2C (IPR015655)
• Protein phosphatase 2C-related (IPR001932)
• Protein phosphatase 2C, manganese/magnesium aspartate binding site (IPR000222)
• Protein phosphatase 2C, N-terminal (IPR014045)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• p53 signaling pathway (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • magnesium ion binding (GO:0000287)
  • protein serine/threonine phosphatase activity (GO:0004722)
  • protein binding (GO:0005515)
  • hydrolase activity (GO:0016787)
  • manganese ion binding (GO:0030145)
• Processes
  • protein amino acid dephosphorylation (GO:0006470)
  • cell cycle (GO:0007049)
  • negative regulation of cell proliferation (GO:0008285)
  • response to radiation (GO:0009314)
• Components
  • nucleus (GO:0005634)
  • protein serine/threonine phosphatase complex (GO:0008287)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
NCL	PPM1D	Invivo	Morimoto H et al.	12185196
NCL	PPM1D	Invitro	Morimoto H et al.	12185196
UNG	PPM1D	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources