Gene: DYNLL1

official authority: DYNLL1, dynein, light chain, LC8-type 1

• Synonyms: DLC1; DLC8; DNCL1; DNCLC1; LC8; LC8a; MGC126137; MGC126138; PIN; hdlc1
• Other Designations: 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; dynein light chain 1; dynein, cytoplasmic, light polypeptide 1; protein inhibitor of neuronal nitric oxide synthase
• Description: dynein, light chain, LC8-type 1
• Type: protein-coding
• Chromosome: 12
• Organism: Homo sapiens
• Omim: 601562
  
• title:Dynein, light chain, LC8-type 1;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000012.11	NM_001037494.1	NP_001032583.1	P63167	1CMI
NC_000012.11	NM_001037495.1	NP_001032584.1	P63167	1CMI
NC_000012.11	NM_003746.2	NP_003737.1	P63167	1CMI

Gene Expression Data

• genes highly correlated to DYNLL1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: DYL1_HUMAN

• Description: Short=PIN;
• Length: 89 aa
• Function: May be involved in some aspects of dynein-related intracellular transport and motility. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
• Location: Cytoplasm.

InterPro domains

• Dynein light chain, type 1 and 2 (IPR001372)
• Dynein light chain, type 1 and 2, conserved site (IPR019763)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Apoptosis (Reactome)

• Cell Cycle, Mitotic (Reactome)

Gene Ontology

• Functions
  • microtubule motor activity (GO:0003777)
  • protein C-terminus binding (GO:0008022)
  • protein domain specific binding (GO:0019904)
• Processes
  • microtubule-based process (GO:0007017)
  • female gamete generation (GO:0007292)
  • activation of pro-apoptotic gene products (GO:0008633)
  • anatomical structure morphogenesis (GO:0009653)
  • actin cytoskeleton organization (GO:0030036)
  • negative regulation of phosphorylation (GO:0042326)
• Components
  • membrane fraction (GO:0005624)
  • cytoplasm (GO:0005737)
  • cytosol (GO:0005829)
  • cytosol (GO:0005829)
  • cytoskeleton (GO:0005856)
  • cytoplasmic dynein complex (GO:0005868)
  • microtubule (GO:0005874)
  • plasma membrane (GO:0005886)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
DNCL1	MYO5A	Invivo	Naisbitt S et al.	10844022
DNCL1	MYO5A	Invitro	Naisbitt S et al.	10844022
DNCL1	MYO5A	Two-hybrid	Naisbitt S et al.	10844022
DNCL1	NOS1	Invivo	Jaffrey SR et al.	8864115
DNCL1	NOS1	Invitro	Jaffrey SR et al.	8864115
DNCL1	NOS1	Two-hybrid	Jaffrey SR et al.	8864115
DNCL1	NFKBIA	Invivo	Crepieux P et al.	9372968
DNCL1	NFKBIA	Invitro	Crepieux P et al.	9372968
DNCL1	NFKBIA	Two-hybrid	Crepieux P et al.	9372968
DNCL1	RAB4A	Two-hybrid	Bielli A et al.	11243854
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources