Gene: GABBR2

official authority: GABBR2, gamma-aminobutyric acid (GABA) B receptor, 2

• Synonyms: FLJ36928; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099
• Other Designations: G protein-coupled receptor 51; OTTHUMP00000021776; OTTHUMP00000063797
• Description: gamma-aminobutyric acid (GABA) B receptor, 2
• Type: protein-coding
• Chromosome: 9
• Organism: Homo sapiens
• Omim: 607340
  
• title:Gamma-aminobutyric acid (GABA) B receptor, 2;
• tissue expression: adrenal gland; brain; connective tissue; embryonic tissue; eye; kidney; lung; muscle; ovary; placenta; skin; testis; thyroid; vascular; adrenal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; lung tumor; normal; ovarian tumor; soft tissue/muscle tissue tumor; embryoid body; fetus; infant; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000009.11	NM_005458.6	NP_005449.5	O75899	---

Gene Expression Data

• genes highly correlated to GABBR2 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: GABR2_HUMAN

• Description: Flags: Precursor;
• Length: 941 aa
• Function: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
• Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.

InterPro domains

• Extracellular ligand-binding receptor (IPR001828)
• GPCR, family 3 (IPR000337)
• GPCR, family 3, C-terminal (IPR017978)
• GPCR, family 3, conserved site (IPR017979)
• GPCR, family 3, gamma-aminobutyric acid receptor, type B (IPR002455)
• GPCR, family 3, gamma-aminobutyric acid receptor, type B2 (IPR002457)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Neuroactive ligand-receptor interaction (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • receptor activity (GO:0004872)
  • G-protein coupled receptor activity (GO:0004930)
  • GABA-B receptor activity (GO:0004965)
  • protein binding (GO:0005515)
• Processes
  • signal transduction (GO:0007165)
  • negative regulation of adenylate cyclase activity (GO:0007194)
  • gamma-aminobutyric acid signaling pathway (GO:0007214)
  • synaptic transmission (GO:0007268)
• Components
  • cytoplasm (GO:0005737)
  • plasma membrane (GO:0005886)
  • integral to plasma membrane (GO:0005887)
  • cell junction (GO:0030054)
  • neuron projection (GO:0043005)
  • synapse (GO:0045202)
  • postsynaptic membrane (GO:0045211)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
GPR51	GABBR1	Invivo	White JH et al.	9872316
GPR51	GABBR1	Two-hybrid	White JH et al.	9872316
GPR51	ATF5	Two-hybrid	White JH et al.	11087824
GPR51	ATF4	Two-hybrid	White JH et al.	11087824
ATF4	GPR51	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources