Research interests are focused on brain aging and neurodegenerative mechanisms, especially those occurring in Parkinson's disease, with particular emphasis on the role of neuromelanin and metals in brain aging and neurodegeneration.
The group of bioinformatics of the Institute of Institute Biomedical Technologies (CNR - ITB) carries out research in the fields of Hight Troughput Computation and distributed infrastructures, System and Computational Biology, Modelling for Novel Devices, Enviromental Bioinformatics and AgroFood Bioinformatics.
Epidemiology is concerned with the patterns of occurrence of diseases and other health events in human populations, and with the factors that influence these patterns, mainly genetics, environment, personal habits, nutrition and exposure to physical or biological agents. It is both a discipline and a body of knowledge about specific diseases.
The branch of biology termed "genomics" aims to study the genome, that is the whole of genes encoded by the DNA of a given cell. The final purpose of genomics is to sequence, map and analyze all the genes in a cell and it necessarily works on a large scale, making use of systematic approaches, the so called "high-throughput" technologies.
One of the challenge of the post-genomic era is represented by the study of molecular Biodiversity in order to understand the biological diversity of organisms in different applied fields such as biomedicine, food and environment.
The newly born unit of Molecular Oncology is focused on the trascription factor C/EBPα, involved in multiple physiological and pathological processes. The research lines of the Unit are aimed at investigating the role that this pleiotropic molecule plays in the regulation of adult stem cells, and in the pathogenesis of inflammatory diseases and various types of cancer.
The main objective of the N&D Unit is to support and promote the activities of the Institute in order to enhance its visibility, foster joint cooperation at national and international level, encourage the exploitation of research results for technology transfer.
The main objectives of Proteomic and Metabolomic Laboratory are related to development and application of innovative methodologies in proteomic studies for characterizing the diagnostic-prognostic markers and/or therapeutic targets in human pathologies, in addition to functional/structural characterization of the molecules identified
Virtually all adult tissues harbour stem cells which, for their proliferation and differentiation abilities, maintain homeostasis and provide potential therapeutical tools in regenerative medicine and tissue engineering.
The lab is committed in 2 major projects. The identification of genes and signaling pathways that regulate stem cell self-renewal in adult tissues in order to prevent genomic instability, tumorigenesis and cancer progression. The identification of genomic and epigenomic factors and signals associated with stem cell fate determination and with stem cell -identity and maintenance and -tissue specific function.
Transcriptional and post-transcriptional regulatory processes of genes involved in physio-pathological cell proliferation by genome-wide investigation to identify molecular biomarkers.