ProCMD : 3D Protein C Mutations Database

Home page

Protein C overview
   The gene
   The protein
         biological function
         mechanism of reaction

Clinical Features

   Find a mutant

Interactive tools
   Multiple alignment
   Model your mutant

ermanna.rovida *



Activated Protein C as a Serine Protease

The Activated Protein C (aPC) belongs to the family of trypsin-like serine proteases. Proteases are a group of enzymes that catalyse the hydrolysis of covalent peptidic bonds within a polypeptide to produce two new smaller peptides. The mechanism of reaction is based on nucleophilic attack of the targeted peptidic bond by a serine and the nucleophilic property of the group is improved by the presence of a histidine, held in a "proton acceptor state" by an aspartate. Aligned side chains of serine, histidine and aspartate build the catalytic triad common to most serine protease (PDB numeration: His 57, Asp 102, Ser 195).