Project

Pathos-17

Identification of molecular mechanisms leading to activation of pathogenic Th1/17 cells by pathobionts and gut microbiota in Crohn’s disease: a new target for therapeutic strategies
Application Areas
Research Areas
Research Lines
Staff
WEBSITE

ITB Principal Investigator

Name

Identification of molecular mechanisms leading to activation of pathogenic Th1/17 cells by pathobionts and gut microbiota in Crohn’s disease: a new target for therapeutic strategies

Acronym

Pathos-17

Location

Segrate

Start Date

2017

End Date

2021

Funder

Fondazione Cariplo

Partners

UniMI-IRCCS Cà Grande Policlinico di Milano (Dipartimenti di Fisiopatologia Medico-Chirurgica e dei Trapianti; Dipartimento di Bioscienze, Gastroenterologia, Malattie Infettive e Malattie Cutanee; Microbiologia)

PaThos17 focuses on the intricate mechanisms of interplay between T lymphocytes (Th1/17 cells) and bacterial pathogens that underline or promote the progression of Chron’s disease. In genetically predisposed subjects, the cells analyzed in this context induce a pro-inflammatory response to specific bacteria, such as Escherichia coli. By leveraging a multidisciplinary approach that combines functional immunology, advanced microbiology, and next-generation sequencing technologies, the Project delves deeply into the cellular and molecular processes that drive a detrimental activation of the adaptive immune system in response to bacterial pathogens. By this multidisciplinary approach, Pathos-17 aims to further advance the understanding of the sophisticated strategies employed by bacterial pathogens to escape immune surveillance and to translate fundamental discoveries, such as novel bacterial and immunological targets, into potential clinical applications
  • AIEC-dependent pathogenic Th17 cell transdifferentiation in Crohn’s disease is suppressed by rfaP and ybaT deletion – DOI