Staff

Martina Scichilone

Assegnista/Borsista
Application Areas
Research Areas
Research Lines
Projects
E-Mail

martinascichilone@cnr.it

PHONE

none

LOCATION

Segrate

ROOM (floor/number)

6/20

I carried out my PhD in Experimental Medicine at Tommaso Selmi’s lab, where I am currently working as a research fellow. I use CRISPR technologies (including Cas9 and base editing) to study how chemical changes on RNA influence tumor cell growth and the development of resistance to cancer therapies (CN3-PNRR project). I am also applying these tools for the functional assessment of genomic regions that might be involved in the response to opioids (PHENOMENA.2 project, PI: Francesca Colombo). I have additionally collaborated with the Genome Editing department at AstraZeneca R&D in Gothenburg, where I contributed to technical advancements in prime editing technologies.

Development of high-throughput CRISPR screening platforms, integrating machine learning-guided library design with large-scale genetic perturbation experiments in different biological contexts

Characterization of the functional landscape of single nucleotide variants (SNV) in disease models by using large-scale CRISPR screens and quantifying variant effects via phenotypic and transcriptional readouts

Regulation of gene expression by transient or constitutive modulation of genes to provide insights into gene function and therapeutic potential in disease models

Determination of how Single Nucleotide Variants (SNVs) in RNA-modification effectors influence cancer cell proliferation and drug resistance

Study of the role of tRNA modifications and tRNA-derived fragments in regulating translation to control stem cell self-renewal and differentiation

Investigation of how specific RNA modifications and ribosome translation dynamics together influence stem and cancer cell proliferation and fate decisions