Project

SATISFY

Generation of patient-specific human tissues for testing the efficacy of new drugs
Application Areas
Research Areas
Research Lines
Staff
WEBSITE

ITB Principal Investigator

Name

Generation of patient-specific human tissues for testing the efficacy of new drugs

Acronym

SATISFY

Location

Segrate

Start Date

2018

End Date

2021

Funder

REGIONE LAZIO, LAZIO INNOVA

Partners

- "Sapienza" University of Rome, Rome, Italy (Prof. R. Rizzi) - Institute of Physical Chemistry - Polish Academy of Sciences, Warsaw, Poland (Dr M. Costantini) - Technion - Israel Institute of Technology, Haifa, Israel (Prof. D. Seliktar) - National Institute of Molecular Genetics (INGM) “Romeo and Enrica Invernizzi”

The SATISFY project is dedicated to the development and validation of a model for the in vitro generation of patient-specific human tissues. The approach is based on the use of induced pluripotent stem cells (iPSCs) combined with advanced expertise in materials engineering and three-dimensional bioprinting. The overall objective is to contribute to the development of reliable biological models for personalized medicine and for the design of new diagnostic and therapeutic strategies. More specifically, one of the project’s main aims is the creation of 3D in vitro organs and tissues for the management of genetic diseases and for the study of patient-tailored treatments. This platform offers new opportunities for drug screening and for the evaluation of innovative therapeutic approaches on models derived from individual patients. Overall, SATISFY seeks to promote tangible progress in regenerative and personalized medicine, while strengthening technology transfer toward the healthcare and industrial sectors.
– Maiullari F, et al. In vivo organized neovascularization induced by 3D bioprinted endothelial-derived extracellular vesicles. Biofabrication (2021) 13(3). doi: 10.1088/1758-5090/abdacf.
– Maiullari F, et al. A multi-cellular 3D bioprinting approach for vascularized heart tissue engineering based on HUVECs and iPSC-derived cardiomyocytes. Sci Rep (2018) 8(1):13532. doi: 10.1038/s41598-018-31848-x.