Fabio Andrea Zucca

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Fabio Andrea Zucca obtained the Master's Degree in Biological Sciences (Molecular Biology) in February 2002 from the University of Milan (Faculty of Mathematical, Physical and Natural Sciences). He was certified for practicing the profession of Biologist in November 2003. In January 2008 he received his Ph.D. from the University of Milan (Faculty of Medicine and Surgery) at the end of the XXth Program of the Doctoral School in Molecular Medicine. His research activities concern the study of brain aging mechanisms and neurodegenerative processes occurring in Parkinson's disease. His main research interest focuses on the characterization of neuromelanin organelles of the human brain with particular emphasis on their biosynthesis, accumulation during brain aging, interaction with metals and other compounds and their role in the neuronal vulnerability.

Interest areas:

Neurochemistry, neurobiology, brain aging, neuronal aging pigments, neuroinflammation, neurodegeneration, Parkinson's disease.


Contacts

Phone: 02 26422622
Fax: 02 26422660
Address: ITB-CNR, Via F.lli Cervi 93 - 20090 Segrate (MI)

International Ids

Scopus Author ID: 6603173218
WoS Researcher ID: O-4368-2015

Research activities classification (ERC)

LIFE SCIENCES
MOLECULAR AND CELLULAR NEUROSCIENCE
NEUROLOGICAL DISORDERS (E.G. ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, PARKINSON'S DISEASE)

Research products

Cupaioli F.A.; Zucca F.A.; Caporale C.; Lesch K.P.; Passamonti L.; Zecca L.

The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects

(2021) in Progress in neuro-psychopharmacology & biological psychiatry
Betts M.J.; Kirilina E.; Otaduy M.C.G.; Ivanov D.; Acosta-Cabronero J.; Callaghan M.F.; Lambert C.; Cardenas-Blanco A.; Pine K.; Passamonti L.; Loane C.; Keuken M.C.; Trujillo P.; Lüsebrink F.; Mattern H.; Liu K.Y.; Priovoulos N.; Fliessbach K.; Dahl M.J.; Maaß A.; Madelung C.F.; Meder D.; Ehrenberg A.J.; Speck O.; Weiskopf N.; Dolan R.; Inglis B.; Tosun D.; Morawski M.; Zucca F.A.; Siebner H.R.; Mather M.; Uludag K.; Heinsen H.; Poser B.A.; Howard R.; Zecca L.; Rowe J.B.; Grinberg L.T.; Jacobs H.I.L.; Düzel E.; Hämmerer D.

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

(2019) in Brain (Online)
Cassidy C.M.; Zucca F.A.; Girgis R.R.; Baker S.C.; Weinstein J.J.; Sharp M.E.; Bellei C.; Valmadre A.; Vanegas N.; Kegeles L.S.; Brucato G.; Kang U. J.; Sulzer D.; Zecca L.; Abi-Dargham A.; Horga G.

Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

(2019) in Proceedings of the National Academy of Sciences of the United States of America
Monzani E.; Nicolis S.; Dell'Acqua S.; Capucciati A.; Bacchella C.; Zucca F.A.; Mosharov E.V.; Sulzer D.; Zecca L.; Casella L.

Dopamine, Oxidative Stress and Protein-Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases

(2019) in Angewandte Chemie (Int. ed., Print)
Segura-Aguilar J.; Sulzer D.; Zucca F.A.; Zecca L.

Overexpression of Vesicular Monoamine Transporter-2 may Block Neurotoxic Metabolites from Cytosolic Dopamine: a Potential Neuroprotective Therapy for Parkinson's Disease

(2019) in Clinical pharmacology and translational medicine Online
Möller H.E.; Bossoni L.; Connor J.R.; Crichton R.R.; Does M.D.; Ward R.J.; Zecca L.; Zucca F.A.; Ronen I.

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

(2019) in Trends in neurosciences (Regul. ed.)
Zucca F.A.; Vanna R.; Cupaioli F.A.; Bellei C.; De Palma A.; Di Silvestre D.; Mauri P.; Grassi S.; Prinetti A.; Casella L.; Sulzer D.; Zecca L.

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease

(2018) in NPJ Parkinson's disease
Sulzer D.; Cassidy C.; Horga G.; Kang U.J.; Fahn S.; Casella L.; Pezzoli G.; Langley J.; Hu X.P.; Zucca F.A.; Isaias I.U.; Zecca L.

Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease

(2018) in NPJ Parkinson's disease
Samarani M.; Loberto N.; Soldà G.; Straniero L.; Asselta R.; Duga S.; Lunghi G.; Zucca F.A.; Mauri L.; Ciampa M.G.; Schiumarini D.; Bassi R.; Giussani P.; Chiricozzi E.; Prinetti A.; Aureli M.; Sonnino S.

A lysosome-plasma membrane-sphingolipid axis linking lysosomal storage to cell growth arrest

(2018) in The FASEB journal
Ferrari E.; Capucciati A.; Prada I.; Zucca F.A.; D'Arrigo G.; Pontiroli D.; Bridelli M.G.; Sturini M.; Bubacco L.; Monzani E.; Verderio C.; Zecca L.; Casella L.

Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson's Disease

(2017) in ACS chemical neuroscience
Visualize all the publications (since 2016)