Our research is declined in the following points:
– Fluorescent tracking of EVs in the human tumor cells
– Characterization of the EVs uniquely released by human tumor cells both in vitro and in vivo.
– Next generation sequencing of RNA species in EVs specifically and uniquely secreted by human tumor cells in vivo, in an appropriate preclinical model (e.g. orthotopic human brain neoplasm in immunodeficient mice).
– Study of tumor spread