Neurodegenerative disorders are relentless progressive diseases and produce care-dependency as well as important health-related public comsumption. So far, we don't know the cause of these disorders and then there are not successful treatments available and some of the drugs use don symptomatic treatments, over time universally become ineffective. Thus, the need to develop more effective treatments for the neurodegenerative disorders is widely recognized, however, as we don't still know the ultimate cause it is difficult to . Moroever, as the degeneration progresses, patients become more and more dependent of the family as well as of the social security, and the truth is that for these diseases there is currently no cure.
The pathogenesis of different neurodegenerative diseases, such as Alzheimer's (AD), Parkinson's (PD), and Huntington's disease (HD), shares several common features. One of these is the abnormal accumulation and aggregation of disease-specific proteins, which is suggested to lead to neurodegeneration. Recent evidence also indicates that the aggregated proteins may spread from one cell or brain area to another and function as seeds to instigate protein misfolding and aggregation in these previously unaffected cells or areas. Genetic mutations or different enviromental factors, such as oxidative or metabolic stress, have been suggested to promote protein mis-folding and aggregation in different neurodegenerative diseases. In fact, the combination of genetic mutations and enviromental factors can induce protein misfolding and aggregation; however, the exact underlying mechanisms of protein aggregation in different neurodegenerative disorders are still not completely understood.
The degeneration factors together with physiological aging and other factors involved in the pathogenic mechanisms underlying these neurodegenerative disorders (such as inflammation and oxidative or metabolic stress and pathogenic disease-associated mutations) could play an important role in determining the onset and progression of the disease and finally causing widespread neuro degeneration in specific brain regions.
Then, this sattelite event looks for discuss the multiple mechanisms of neurodegeneration in different diseases as well as to analyze the posible causes of the cell death progression. This may provide novel opportunities to better understand the disease pathogenesis and subsequently to identify new disease biomarkers and therapeutic targets for an earlier diagnosis and treatment of patients suffering from different neurodegenerative disorders. The speakers will discuss offering their expertise in several fields of neurodegeneration and all together can explain to each other some causes of the gradual progression of the disease pathology in the brain over time (at least in the case of the most prevalent neurodegenerative disorders).
Among the speakers will be included some neurologists in order to analyze the impact at the clinical level. The satellite is open to PhD students in order to get them the opportunity of sharing the knowlegde as well as to discuss in a relaxed atmosphere with some of the leaders of the neurodegeneration field.
The satellite is organized by the Neurotoxicity Society (NTS). Our society is devote to unite basic and clinical scientists in the Neurotoxicity field, and its aims are:
• foster scientific interaction directed towards increased understanding of processes, mechanisms, and outcomes of neurodegeneration, nerve regeneration, neuroprotection, neurotrophin actions, and the associated role of glia and other satellite cells;
• facilitate the advance of preclinical research discoveries to clinical and medical utility;
• promote dissemination of knowledge on these topics to the public;
• host scientific meetings on a neurotoxicity theme, at regular intervals.
The idea of Programme Schedule of the satellite includes 4 basic and clinical topics plus a session for free communications based on abstract presentation. The total time of the satellite will be 20 hours
The four programmed topics will be: i) prenatal factors; ii) chemical stress; iii) genetic and epigenetic factors; iv) inflammation and immune system.
July 10, 2014 - July 11, 2014
Venue: Hotel Splendid – Baveno (Lago Maggiore), Strada Statale del Sempione, 12, 28831- Baveno, Italy, Baveno (28831), Italy
Organizers: Prof. María Trinidad Herrero (Castelló, Spain) & Prof. Micaela Morelli (Cagliari, Italy) & Neurotoxicity Society (NTS)
Contact person(s): María Trinidad Herrero, +34609441977; Micaela Morelli, +390706758663;
Secretary: Francine Verhagen, +39 3484680287 or +39 070749146
Website announcing the Satellite event programme: http://www.neurotoxicitysociety.org/