Antonella De Palma

The information published in this page are entirely managed by ANTONELLA DE PALMA who is completely responsible for it.

Antonella De Palma obtained the Master's Degree in Medicinal Chemistry and Pharmaceutical Technology (Faculty of Pharmacy) in 2004 from the University of Pavia (110/110, cum laude). In the same year she achieved the Professional abilitation in Pharmacy. Over the years, she acquired a number of analytical skills on mono- and bi-dimensional liquid chromatographic systems (based on capillary-, micro- and nano-LC and UHPLC technologies) combined to high resolution and fast sequencing speed mass spectrometers (ion traps and hybrid mass spectrometers based on Orbitrap technology) equipped with different ion sources. From 2012 she has a permanent position at ITB-CNR, as full-time researcher, and her work concerns the development and the application of innovative LC-MS platforms for the identification and "label-free" quantification of bioactive molecules in complex biological matrices. In particular, she is exploiting these high-throughput "-omics" technologies combined with powerful computational and bioinformatics tools to answer questions in the biomedical field: increasing large-scale proteome and metabolome knowledge, allowing detection and validation of differentially expressed proteins as potential biomarkers of physio- pathological states and reaching a deepened and precise investigation of biological processes in which they are involved. She also has a notable experience in the mass spectrometry data handling, in the interpretation of the biological significance of the results and in the structural and functional characterization of proteins, either individually or as part of complex, through bottom-up and top-down approaches.

Interest areas:

Mass spectrometry, liquid chromatography, innovative LC-MS platforms, Proteomics, Metabolomics, Systems Biology, label-free quantitation, biomarker discovery.


Phone: 0226422732
Fax: 0226422770
Skype: antodepa78
Address: ITB-CNR, Via Fratelli Cervi n.93, 20090 Segrate (MI)

International Ids


Google Scholar H-Index: 15
Scopus H-Index: 13
ISI-WoS H-Index: 13

Research activities classification (ERC)


Research products

Antonella De Palma, Giulia Fanelli, Elisabetta Cretella, Veronica De Luca, Raffaele Antonio Palladino, Valentina Panzeri, Valentina Roffia, Michele Saliola, Pierluigi Mauri, Patrizia Filetici

Gcn5p and Ubp8p Affect Protein Ubiquitylation and Cell Proliferation by Altering the Fermentative/Respiratory Flux Balance in Saccharomyces cerevisiae

(2020) in MBio
Erika Ponzini1, Antonella De Palma2, Lucilla Cerboni1, Antonino Natalello3, Rossana Rossi4, Rani Moons5, Albert Konijnenberg5, Joanna Narkiewicz6, Giuseppe Antonio Legname7, Frank Sobott8, Pierluigi Mauri4, Carlo Santambrogio1* and Rita Grandori9

Methionine oxidation in ?-synuclein inhibits its propensity for ordered secondary structure

(2019) in The Journal of biological chemistry (Print)
Ferrari E.; Wittig A.; Basilico F.; Rossi R.; De Palma A.; Di Silvestre D.; Sauerwein W.A.G.; Mauri P.L.

Urinary proteomics profiles are useful for detection of cancer biomarkers and changes induced by therapeutic procedures

(2019) in Molecules (Basel, Online)
Ponzini E, De Palma A, Cerboni L, Natalello A, Rossi R, Moons R, Konijnenberg A, Narkiewicz J, Legname G, Sobott F, Mauri P, Santambrogio C, Grandori R.

Methionine oxidation in ?-synuclein inhibits its propensity for ordered secondary structure

(2019) in Journal of biological chemistry (Online)
Roffia V.; De Palma A.; Lonati C.; Di Silvestre D.; Rossi R.; Mantero M.; Gatti S.; Dondossola D.; Valenza F.; Mauri P.; Blasi F.

Proteome investigation of rat lungs subjected to Ex vivo perfusion (EVLP)

(2018) in Molecules (Basel, Online)
Zucca F.A.; Vanna R.; Cupaioli F.A.; Bellei C.; De Palma A.; Di Silvestre D.; Mauri P.; Grassi S.; Prinetti A.; Casella L.; Sulzer D.; Zecca L.

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease

(2018) in NPJ Parkinson's disease
Canetti, Diana; Rendell, Nigel Brian; Di Vagno, Lucia; Gilbertson, Janet A; Rowczenio, Dorota; Rezk, Tamar; Gillmore, Julian D; Hawkins, Phillip N; Verona, Guglielmo; Mangione, Palma Patrizia; Giorgetti, Sofia; Mauri, Pierluigi; Motta, Sara; De Palma, Antonella; Bellotti, Vittorio; Taylor, Graham W

Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue.

(2017) in Amyloid (Carnforth)
Bonanomi, Marcella; Roffia, Valentina; De Palma, Antonella; Lombardi, Alessio; Aprile, Francesco Antonio; Visentin, Cristina; Tortora, Paolo; Mauri, Pierluigi; Regonesi, Maria Elena

The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris

(2017) in Scientific reports (Nature Publishing Group)
Ferrari, Emanuele; De Palma, Antonella; Mauri, Pierluigi

Emerging MS-based platforms for the characterization of tumor-derived exosomes isolated from human biofluids: challenges and promises of MudPIT

(2017) in Expert review of proteomics (Print)
Agresta, Anna Maria; De Palma, Antonella; Bardoni, Anna; Salvini, Roberta; Iadarola, Paolo; Mauri, Pier Luigi

Proteomics as an innovative tool to investigate frontotemporal disorders

(2016) in Proteomics. Clinical applications (Print)
Visualize all the publications (since 2016)