Antonella De Palma obtained the Master's Degree in Medicinal Chemistry and Pharmaceutical Technology (Faculty of Pharmacy) in 2004 from the University of Pavia (110/110, cum laude). In the same year she achieved the Professional abilitation in Pharmacy. Over the years, she acquired a number of analytical skills on mono- and bi-dimensional liquid chromatographic systems (based on capillary-, micro- and nano-LC and UHPLC technologies) combined to high resolution and fast sequencing speed mass spectrometers (ion traps and hybrid mass spectrometers based on Orbitrap technology) equipped with different ion sources. From 2012 she has a permanent position at ITB-CNR, as full-time researcher, and her work concerns the development and the application of innovative LC-MS platforms for the identification and "label-free" quantification of bioactive molecules in complex biological matrices. In particular, she is exploiting these high-throughput "-omics" technologies combined with powerful computational and bioinformatics tools to answer questions in the biomedical field: increasing large-scale proteome and metabolome knowledge, allowing detection and validation of differentially expressed proteins as potential biomarkers of physio- pathological states and reaching a deepened and precise investigation of biological processes in which they are involved. She also has a notable experience in the mass spectrometry data handling, in the interpretation of the biological significance of the results and in the structural and functional characterization of proteins, either individually or as part of complex, through bottom-up and top-down approaches.
Mass spectrometry, liquid chromatography, innovative LC-MS platforms, Proteomics, Metabolomics, Systems Biology, label-free quantitation, biomarker discovery.
Orcid ID: 0000-0001-5937-8604
Other info & publications here: antonella.depalma