Francesca Colombo

The information published in this page are entirely managed by FRANCESCA COLOMBO who is completely responsible for it.

I have been studying lung cancer genetics for over 12 years, since the start of my scientific career. I have been involved in the identification and functional characterization of genes and genetic variants associated with the development or progression of lung cancer, focusing on adenocarcinoma histotype. In particular, I have carried out genome-wide association studies (GWAS), using genotyping data obtained by SNP-array, I performed in vitro functional assays to test the effects of different allelic variants in coding or regulatory regions and I conducted analyses for the identification of quantitative expression trait loci (eQTLs), combining transcriptomic and genomic data. In recent years, I have extended my interests to pharmacogenetics/pharmacogenomics, particularly in the field of smoking cessation therapies and opioid therapy for cancer pain. In addition, I have also recently started working on pharmacogenomics of immune checkpoint inhibitors in patients with advanced lung cancer. I have extensive technical skills in cell-molecular biology and statistics competence. I also have experience in research management (e.g. planning experiments, coordinating collaborators). I currently collaborate with several clinicians, including medical oncologists, pneumologists and palliative care experts.

Other publication name:

Colombo F

Interest areas:

Cancer genetics Genetic epidemiology Population genetics Pharmacogenetics/Pharmacogenomics Transcriptomics Molecular oncology


Contacts


International Ids

Scopus Author ID: 24402710900
WoS Researcher ID: Q-5292-2019

H-indexes

Google Scholar H-Index: 11
Scopus H-Index: 10
ISI-WoS H-Index: 9

Experience

Research fellow
Company: Fondazione Umberto Veronesi - Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Time period: 02/2017 - 11/2019

Recepient of research fellowship awards from Fondazione Umberto Veronesi, in 2017, 2018 and 2019


Post-doc
Company: Fondazione IRCCS Istituto Nazionale dei Tumori
Time period: 07/2011 - 01/2017

PhD student
Company: Fondazione IRCCS Istituto Nazionale dei Tumori
Time period: 03/2007 - 06/2011

PhD student (Open University, Milton Keynes, UK) in Biomolecular and Life Sciences Thesis title: "Functional analyses of genetic elements associated with lung cancer"



Education

Master universitario di secondo livello in Statistica Medica e Genomica
Università degli Studi di Pavia
Graduation date: 2017-11-29
Attendance time period: 2015 - 2017
Thesis: Genome-wide survival analysis of lung adenocarcinoma patients

PhD in Biomolecular and Life Sciences
Open University - Milton Keynes, UK - Affiliated Reesearch Center: Fondazione IRCCS Istituto Nazionale dei Tumori (MI, Italy)
Graduation date: 2011-06-24
Attendance time period: 2007 - 2011
Thesis: Functional analyses of genetic elements associated with lung cancer

Biotecnologie Mediche Molecolari e Cellulari
Libera Università Vita Salute San Raffaele di Milano
Grade: 110 e/110
Graduation date: 2006-09-25
Attendance time period: 10/2004 - 09/2006
Thesis: Ruolo dei geni TRIT1 e MFSD2 nella progressione del tumore polmonare

Biotecnologie
Università degli Studi dell'Insubria - Varese
Grade: 110 e/110
Graduation date: 2004-09-26
Attendance time period: 10/2001 - 09/2004
Thesis: Studio in vitro degli effetti biologici del gene umano UNC93A, presunto tumor suppressor gene della regione 6q27, in un modello cellulare murino


Research products

Chiara E Cotroneo, Nunzia Mangano, Tommaso A Dragani, Francesca Colombo

Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants

(2021) in European journal of human genetics (Online)
Fallerini, Chiara; Daga, Sergio; Benetti, Elisa; Picchiotti, Nicola; Zguro, Kristina; Catapano, Francesca; Baroni, Virginia; Lanini, Simone; Bucalossi, Alessandro; Marotta, Giuseppe; Colombo, Francesca; Baldassarri, Margherita; Fava, Francesca; Beligni, Giada; Di Sarno, Laura; Alaverdian, Diana; Palmieri, Maria; Croci, Susanna; Isidori, Andrea M.; Furini, Simone; Frullanti, Elisa; Renieri, Alessandra; Mari, Francesca

SELP Asp603Asn and severe thrombosis in COVID-19 males

(2021) in Journal of hematology & oncology
Colombo, Francesca; Pintarelli, Giulia; Galvan, Antonella; Noci, Sara; Corli, Oscar; Skorpen, Frank; Klepstad, Pål; Kaasa, Stein; Pigni, Alessandra; Brunelli, Cinzia; Roberto, Anna; Piazza, Rocco; Pirola, Alessandra; Gambacorti-Passerini, Carlo; Caraceni, Augusto Tommaso

Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients

(2020) in Scientific reports (Nature Publishing Group)
Maspero, Davide; Dassano, Alice; Pintarelli, Giulia; Noci, Sara; De Cecco, Loris; Incarbone, Matteo; Tosi, Davide; Santambrogio, Luigi; Dragani, Tommaso A.; Colombo, Francesca

Read-through transcripts in lung: germline genetic regulation and correlation with the expression of other genes

(2020) in Carcinogenesis (N.Y., Print)
Dragani, Tommaso A.; Matarese, Valerie; Colombo, Francesca

Biomarkers for Early Cancer Diagnosis: Prospects for Success through the Lens of Tumor Genetics

(2020) in BioEssays
Pintarelli, Giulia; Noci, Sara; Maspero, Davide; Pettinicchio, Angela; Dugo, Matteo; De Cecco, Loris; Incarbone, Matteo; Tosi, Davide; Santambrogio, Luigi; Dragani, Tommaso A.; Colombo, Francesca

Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients

(2019) in Scientific reports (Nature Publishing Group)
van den Berge, Maarten; Brandsma, Corry Anke; Faiz, Alen; de Vries, Maaike; Rathnayake, Senani N.H.; Paré, Peter D.; Sin, Don D.; Bossé, Yohan; Laviolette, Michel; Nickle, David C.; Hao, Ke; Obeidat, Ma'en; Dragani, Tommaso A.; Colombo, Francesca; Timens, Wim; Postma, Dirkje S.

Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD

(2019) in The European respiratory journal
Dragani, Tommaso A.; Colombo, Francesca; Pavlisko, Elizabeth N.; Roggli, Victor L.

Corrigendum: Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure (Carcinogenesis (bgy145) DOI: 10.1093/carcin/bgy145)

(2019) in Carcinogenesis (N.Y., Print)
Dragani, Tommaso A.; Colombo, Francesca; Pavlisko, Elizabeth N.; Roggli, Victor L.

Response to comments on 'Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure' by Farioli et al. and Oddone et al.

(2019) in Carcinogenesis (N.Y., Print)
Dragani, Tommaso A.; Colombo, Francesca; Pavlisko, Elizabeth N.; Roggli, Victor L.

Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure

(2018) in Carcinogenesis (N.Y., Print)
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