I have been studying lung cancer genetics for over 12 years, since the start of my scientific career. I have been involved in the identification and functional characterization of genes and genetic variants associated with the development or progression of lung cancer, focusing on adenocarcinoma histotype. In particular, I have carried out genome-wide association studies (GWAS), using genotyping data obtained by SNP-array, I performed in vitro functional assays to test the effects of different allelic variants in coding or regulatory regions and I conducted analyses for the identification of quantitative expression trait loci (eQTLs), combining transcriptomic and genomic data. In recent years, I have extended my interests to pharmacogenetics/pharmacogenomics, particularly in the field of smoking cessation therapies and opioid therapy for cancer pain. In addition, I have also recently started working on pharmacogenomics of immune checkpoint inhibitors in patients with advanced lung cancer. I have extensive technical skills in cell-molecular biology and statistics competence. I also have experience in research management (e.g. planning experiments, coordinating collaborators). I currently collaborate with several clinicians, including medical oncologists, pneumologists and palliative care experts.
Colombo F
Cancer genetics Genetic epidemiology Population genetics Pharmacogenetics/Pharmacogenomics Transcriptomics Molecular oncology
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International Ids
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Experience
Company: Fondazione Umberto Veronesi - Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Time period: 02/2017 - 11/2019 Recepient of research fellowship awards from Fondazione Umberto Veronesi, in 2017, 2018 and 2019 |
Company: Fondazione IRCCS Istituto Nazionale dei Tumori Time period: 07/2011 - 01/2017 |
Company: Fondazione IRCCS Istituto Nazionale dei Tumori Time period: 03/2007 - 06/2011 PhD student (Open University, Milton Keynes, UK) in Biomolecular and Life Sciences Thesis title: "Functional analyses of genetic elements associated with lung cancer" |
Education
Università degli Studi di Pavia Graduation date: 2017-11-29 Attendance time period: 2015 - 2017 Thesis: Genome-wide survival analysis of lung adenocarcinoma patients |
Open University - Milton Keynes, UK - Affiliated Reesearch Center: Fondazione IRCCS Istituto Nazionale dei Tumori (MI, Italy) Graduation date: 2011-06-24 Attendance time period: 2007 - 2011 Thesis: Functional analyses of genetic elements associated with lung cancer |
Libera Università Vita Salute San Raffaele di Milano Grade: 110 e/110 Graduation date: 2006-09-25 Attendance time period: 10/2004 - 09/2006 Thesis: Ruolo dei geni TRIT1 e MFSD2 nella progressione del tumore polmonare |
Università degli Studi dell'Insubria - Varese Grade: 110 e/110 Graduation date: 2004-09-26 Attendance time period: 10/2001 - 09/2004 Thesis: Studio in vitro degli effetti biologici del gene umano UNC93A, presunto tumor suppressor gene della regione 6q27, in un modello cellulare murino |
