Federica Chiappori

Federica Chiappori svolge attività di ricerca in ambito bioinformatico presso l'ITB-CNR dal 2006 ed è ricercatrice dal 2020. Dopo una laurea in Bioinformatica nel 2005 e un dottorato in Scienze per l'ambiente e la salute pubblica nel 2010, la sua attività di ricerca si sviluppa nell'ambito della modellistica molecolare di strutture proteiche e non. Ha oltre 15 anni di esperienza in studi di correlazione struttura-funzione, analisi d'interazione e disegno di composti con potenziale attività farmacologica. Principalmente impiega tecniche di dinamica molecolare, docking per lo studio di complessi proteina-ligando, proteina-proteina e proteina-RNA, in ambito HPC. Più recentemente si è occupata delle alterazioni del microbioma (batteri e funghi) e dei suoi effetti, con l'impego di tecniche di analisi di metagenomica. Svolge funzioni di revisore per riviste e progetti nazionali e internazionali. Ed è socio ordinario della società scientifica BITS.

biologia computazionale, struttura proteica, dinamica molecolare, effetto SNP sulla struttura proteica, allosteria, modificazioni post-traduzionali, trasduzione del segnale, legame con ligandi, docking, metagenomica, interazione ospite-batteri, microbioma intestinale

Digenic inheritance of subclinical variants in Noonan Syndrome patients: an alternative pathogenic model?

Microbiota Profile in Autism Spectrum Disorder: Different Metagenomics Approaches to analyze 16S and 18S rRNA

Association of Haptoglobin-1 allele with Autism

The role of extracellular matrix in mouse and human corneal neovascularization

CXCL10 binding mode to CXCR3 isoforms: different behaviors

CXCL10-CXCR3 complex formation, different isoforms result in different binding modes

Antarctic marine ciliates under stress: superoxide dismutases from the psychrophilic Euplotes focardii are cold-active yet heat tolerant enzymes

High parathyroid hormone concentration in tenofovir-treated patients are due to inhibition of calcium-sensing receptor activity.

Association of Haptoglobin-1 allele with Autism.

Gliadin peptide deamidation: effects on CXCR3 binding and signal transmission

Effect of gliadin modification on CXCR3 binding

Identification of molecular determinants of CXCR3-gliadin-mediated triggering of intestinal permeability

HPC analysis of multiple binding sites communication and allosteric modulations in drug design: The HSP case study

A novel molecular dynamics approach to evaluate the effect of phosphorylation on multimeric protein interface: the alpha B-Crystallin case study

An atomistic view of Hsp70 allosteric crosstalk: From the nucleotide to the substrate binding domain and back

Clustering protein structures with Hadoop

Effect of serine phosphorylation on aB-Crystallin interface multimeric form

Autism and intestinal permeability: bioinformatics selection of candidate genes target

Allosteric modulation: the Hsp70 case study

Allosteric cross-talk between nucleotide and substrate binding domains in Hsp70: an atomistic view

DnaK as Antibiotic Target: Hot Spot Residues Analysis for Differential Inhibition of the Bacterial Protein in Comparison with the Human HSP70

Thermal and ionic effect on Euplotes focardii superoxide dismutase structure

Neuromics

Psychrophilic protein modeling

Identification and analysis of two sequences encoding ice-binding proteins obtained from a putative bacterial symbiont of the psychrophilic Antarctic ciliate Euplotes focardii

Protein threading modeling approaches for describing the structural conformation of the Calcium-sensing receptor cytoplasmic C-terminal portion.

Tubulin folding: the special case of a beta-tubulin isotype from the Antarctic psychrophilic ciliate Euplotes focardii

Cloud infrastructures for in silico drug discovery: economic and practical aspects

Static and dynamic interactions between GALK enzyme and known inhibitors: Guidelines to design new drugs for galactosemic patients

Molecular Mechanism of Allosteric Communication in Hsp70 Revealed by Molecular Dynamics Simulations

Comparative analysis of the human Hsp70 and of the bacterial homolog DnaK for the identification of key differential interaction residues through Molecular Dynamics simulations

Molecular Mechanism of Allosteric Communication in Hsp70 Revealed by Molecular Dynamics Simulations

Structural thermal adaptation of beta-tubulins from the Antarctic psychrophilic protozoan Euplotes focardii

The Analysis of Interactions Between Galk Enzyme and Known Inhibitors Suggests Guidelines to Develop New Drugs for Galactosemic Patients.

Computational Biology Strategy for the Development of Ligands of GALK Enzyme as Potential Drugs for People with Classical Galactosemia.

Exploring the role of the phospholipid ligand in Endothelial Protein C Receptor: a molecular dynamics study

In silico saturation mutagenesis and docking screening for the analysis of protein-ligand interaction: the Endothelial Protein C Receptor case study

Virtual screening pipeline and ligand modelling for H5N1 neuraminidase

A Docking Procedure for the identification of potential Bisphenol A’ protein targhets and characterization of the major environmental matrix involved in their pathways

A pipeline for saturation mutagenesis and docking, applied to the endothelial protein C receptor .

Pipeline for saturation mutagenesis and docking screening in the study of protein-ligand interaction: the Endothelial Protein C Receptor (EPCR)

Grid docking simulation for comparative ligand binding of Neurominidase structures