The information published in this page are entirely managed by LUIGI ZECCA who is completely responsible for it.
Luigi Zecca MD is a leading scientist in the field of neuromelanins and metals in the human brain. He has been visiting scientist at Brookhaven National Laboratory (Upton, NY, USA), at Dartmouth Medical School (Hanover, NH, USA), at University of Wuerzburg (Wuerzburg, Germany) and currently at Columbia University (New York, NY, USA). He has described with his collaborators key aspects on the structure, synthesis, interaction with metals and role of neuromelanins. In particular, he has shown that neuromelanins are ubiquitous in the human brain, occur in special autolysosomes and accumulate in aging. His studies have demonstrated a link between aging and neurodegeneration in Parkinson's disease mediated by neuromelanin. He has also shown that neuromelanins can play either a protective or toxic role depending on the cellular context in brain aging and Parkinson's disease. He has described the paramagnetic and other physico-chemical properties of the neuromelanin-iron complex that are the fundamentals which allowed the development of magnetic resonance imaging of neuromelanin, which is nowadays used as new tool for diagnosis of Parkinson. He has found that neuromelanins released by degenerating neurons in Parkinson's disease can activate microglia which cause neuronal death and further release of neuromelanin, thus establishing a vicious cycle of neuroinflammation and neurodegeneration, that contributes to the progression the disease. He is currently interested in the structure and pathways of neuromelanin autolysosomal organelles in neurons during aging. Moreover, he is investigating contrast mechanisms associated with magnetic resonance imaging of the neurodegeneration in Alzheimer's and Parkinson's diseases.
Interest areas:
Neurochemistry, neurobiology, brain aging, neuromelanin, neuromelanin-sensitive magnetic resonance, neuroinflammation, neurodegeneration, Parkinson's disease, magnetic resonance imaging.
Contacts
International Ids
Orcid ID: 0000-0002-7409-6653
Research products
Cupaioli F.A.; Zucca F.A.; Caporale C.; Lesch K.P.; Passamonti L.; Zecca L.
The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects
(2021) in Progress in neuro-psychopharmacology & biological psychiatry
Capucciati A.; Zucca F.A.; Monzani E.; Zecca L.; Casella L.; Hofer T.
Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models
(2021) in Antioxidants
Zecca L, Pifl C, Fahn S, Sulzer D, Fariello RG
Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease.
(2021) in NPJ Parkinson's disease
Cassidy CM, Carpenter KM, Konova AB, Cheung V, Grassetti A, Zecca L, Abi- Dargham A, Martinez D, Horga G
Evidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI
(2020) in The American Journal of Psychiatry (Greece Ed. select. articl.)
Sulzer D, Antonini A, Leta V, Nordvig A, Smeyne RJ, Goldman JE, Al-Dalahmah O, Zecca L, Sette A, Bubacco L, Meucci O, Moro E, Harms AS, Xu Y, Fahn S, Ray Chaudhuri K
COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside
(2020) in NPJ Parkinson's disease
Segura-Aguilar J.; Sulzer D.; Zucca F.A.; Zecca L.
Overexpression of Vesicular Monoamine Transporter-2 may Block Neurotoxic Metabolites from Cytosolic Dopamine: a Potential Neuroprotective Therapy for Parkinson's Disease
(2019) in Clinical pharmacology and translational medicine Online
Monzani E.; Nicolis S.; Dell'Acqua S.; Capucciati A.; Bacchella C.; Zucca F.A.; Mosharov E.V.; Sulzer D.; Zecca L.; Casella L.
Dopamine, Oxidative Stress and Protein-Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases
(2019) in Angewandte Chemie (Int. ed., Print)
Barichella M, Severgnini M, Cilia R, Cassani E, Bolliri C, Caronni S, Ferri V, Cancello R, Ceccarani C, Faierman S, Pinelli G, De Bellis G, Zecca L, Cereda E, Consolandi C, Pezzoli G.
Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism
(2019) in Movement disorders
Möller H.E.; Bossoni L.; Connor J.R.; Crichton R.R.; Does M.D.; Ward R.J.; Zecca L.; Zucca F.A.; Ronen I.
Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology
(2019) in Trends in neurosciences (Regul. ed.)
Cassidy C.M.; Zucca F.A.; Girgis R.R.; Baker S.C.; Weinstein J.J.; Sharp M.E.; Bellei C.; Valmadre A.; Vanegas N.; Kegeles L.S.; Brucato G.; Kang U.J.; Sulzer D.; Zecca L.; Abi-Dargham A.; Horga G.
Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain
(2019) in Proceedings of the National Academy of Sciences of the United States of America
Andrea Capucciati Monica Galliano Luigi Bubacco Luigi Zecca Luigi* Casella Enrico Monzani Stefania Nicolis
Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases
(2019) in ACS chemical neuroscience
Betts M.J.; Kirilina E.; Otaduy M.C.G.; Ivanov D.; Acosta-Cabronero J.; Callaghan M.F.; Lambert C.; Cardenas-Blanco A.; Pine K.; Passamonti L.; Loane C.; Keuken M.C.; Trujillo P.; Lüsebrink F.; Mattern H.; Liu K.Y.; Priovoulos N.; Fliessbach K.; Dahl M.J.; Maaß A.; Madelung C.F.; Meder D.; Ehrenberg A.J.; Speck O.; Weiskopf N.; Dolan R.; Inglis B.; Tosun D.; Morawski M.; Zucca F.A.; Siebner H.R.; Mather M.; Uludag K.; Heinsen H.; Poser B.A.; Howard R.; Zecca L.; Rowe J.B.; Grinberg L.T.; Jacobs H.I.L.; Düzel E.; Hämmerer D.
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.
(2019) in Brain (Online)
Zucca F.A.; Vanna R.; Cupaioli F.A.; Bellei C.; De Palma A.; Di Silvestre D.; Mauri P.; Grassi S.; Prinetti A.; Casella L.; Sulzer D.; Zecca L.
Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease
(2018) in NPJ Parkinson's disease
Sulzer D.; Cassidy C.; Horga G.; Kang U.J.; Fahn S.; Casella L.; Pezzoli G.; Langley J.; Hu X.P.; Zucca F.A.; Isaias I.U.; Zecca L.
Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease
(2018) in NPJ Parkinson's disease
Zucca F.A.; Segura-Aguilar J.; Ferrari E.; Muñoz P.; Paris I.; Sulzer D.; Sarna T.; Casella L.; Zecca L.
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
(2017) in Progress in neurobiology (Print)
Ferrari E.; Capucciati A.; Prada I.; Zucca F.A.; D'Arrigo G.; Pontiroli D.; Bridelli M.G.; Sturini M.; Bubacco L.; Monzani E.; Verderio C.; Zecca L.; Casella L.
Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson's Disease
(2017) in ACS chemical neuroscience
Trujillo P.; Summers P.E.; Ferrari E.; Zucca F.A.; Sturini M.; Mainardi L.T.; Cerutti S.; Smith A.K.; Smith S.A.; Zecca L.; Costa A.
Contrast mechanisms associated with neuromelanin-MRI
(2017) in Magnetic resonance in medicine (Print)
Zecca L.; Isaias I.U.; Casella L.; Sulzer D.; Zucca F.A.
Protective and toxic role of neuromelanin in brain aging and Parkinson's disease
(2016) Dopamine 2016, Campus of the University of Vienna, Vienna, Austria, 5-8/09/2016
Biesemeier A.; Eibl O.; Eswara S.; Audinot J.N.; Wirtz T.; Pezzoli G.; Zucca F.A.; Zecca L.; Schraermeyer U.
Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry
(2016) in Journal of neurochemistry
Isaias, Ioannis U.; Trujillo, Paula; Summers, Paul; Marotta, Giorgio; Mainardi, Luca; Pezzoli, Gianni; Zecca, Luigi; Costa, Antonella
Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease
(2016) in Frontiers in aging neuroscience
Cassidy C.; Zecca L.; Ferrari E.; Zucca F.A.; Weinstein J.; Baker S.; Benavides C.; Kang U.; Sulzer D.; Abi-Dargham A.; Horga G.
Neuromelanin-sensitive MRI as a proxy-measure of dopamine function in neuropsychiatric illness.
(2016) Dopamine 2016, Campus of the University of Vienna, Vienna, Austria, 5-8/09/2016
Zecca L, Isaias I, Casella L, Capucciati A, Ferrari E, Horga G, Cassidy C, Sulzer D and Zucca FA
The role of neuromelanins in the oxidative stress of Parkinson's disease.
(2016) Xth International Workshop on EPR in Biology and Medicine, Krakow, Poland, 2-6/10/2016
Deb S.; Ferrari E.; Zucca F.A.; Zecca L.; Warren W.S.
Application of Pump-Probe Imaging Towards Chemical and Structural Characterization of Neuromelanin.
(2016) World Molecular Imaging Congress (WMIC) 2016, New York, NY, USA, 7-10/09/2016
Zecca L.; Cebrián C.; Mauri P.; Isaias I.; Casella L.; Zucca F.A.; Sulzer D.
The structure, synthesis and role of neuromelanins in brain aging and neurodegeneration
(2015) PanAmerican Society for Pigment Cell Research - PASPCR Conference 2015, Orange, California, USA, 27-30/09/2015.
Zecca L.; Zucca F.A.; Casella L.; Sarna T.
Neuromelanins, oxidative stress and Parkinson's disease
(2015) Winter School - Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University in Krakow From Genome to Proteome, Zakopane, Poland, February 10-14 2015
Zecca L.; Bellei C.; Mauri P.; Casella L.; Cebrián C.; Sulzer D., Zucca F.A.
The protective and toxic role of neuromelanins in brain aging and Parkinson's disease
(2015) European Society for Neurochemistry's Conference Molecular Mechanisms of Regulation in the Nervous System, Tartu, Estonia, June 14-17, 2015
Zecca L.; Cebrian C.; Sulzer D.; Zucca F.A.
The neurodegenerative role of neuromelanin in Parkinson's disease
(2015) VII NEUROTOXICITY SOCIETY MEETING, Cuenca, Spain, 12 April 2015 - 16 April 2015
d'Ischia M.; Wakamatsu K.; Cicoira F.; Di Mauro E.; Garcia-Borron J.C.; Commo S.; Galván I.; Ghanem G.; Kenzo K.; Meredith P.; Pezzella A.; Santato C.; Sarna T.; Simon J.D.; Zecca L.; Zucca F.A.; Napolitano A.; Ito S.
Melanins and melanogenesis: from pigment cells to human health and technological applications
(2015) in Pigment cell & melanoma research (Print)
Wakamatsu K.; Tabuchi K.; Ojika M.; Zucca F.A.; Zecca L.; Ito S.
Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus
(2015) in Journal of neurochemistry
Zecca L.; Ferrari E.; Bellei C.; Mauri P.; Casella L.; Sarna T.; Zucca F.A.
Neuromelanin organelles pathways in brain aging and Parkinson's disease
(2014) Zing Conference on Oxidative Stress, Parador de Oropesa, Spain, October 3 - 6, 2014
Zecca L.; Cebrián C.; Ferrari E.; Bellei C.; Cupaioli F.A.; De Palma A.; Mauri P.; Casella L.; Sulzer D.; Zucca F.A.
The role of neuromelanin organelle pathways in parkinson's disease
(2014) Multiple mechanisms of neurodegeneration and progression, Milano FENS 2014 - NTS Satellite Symposium, Baveno, Italy, July 10 - 11, 2014
Cupaioli F.A.; Zucca F.A.; Boraschi D.; Zecca L.
Engineered nanoparticles. How brain friendly is this new guest?
(2014) in Progress in neurobiology (Print)
Wakamatsu K.; Tanaka H.; Tabuchi K.; Ojika M.; Zucca F.A.; Zecca L.; Ito S.
Reduction of the Nitro Group to Amine by Hydroiodic Acid to Synthesize o-Aminophenol Derivatives as Putative Degradative Markers of Neuromelanin
(2014) in Molecules (Basel, Online)
Cebrian C.; Zucca F.A.; Mauri P.; Steinbeck J.A.; Studer L.; Scherzer C.R.; Kanter E.; Budhu S.; Mandelbaum J.; Vonsattel J.P.; Zecca L.; Loike J.D.; Sulzer D.
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
(2014) in Nature communications
Ward R.J.; Zucca F.A.; Duyn J.H.; Crichton R.R.; Zecca L.
The role of iron in brain ageing and neurodegenerative disorders
(2014) in Lancet neurology (Print)
Zucca F.A.; Basso E.; Cupaioli F.A.; Ferrari E.; Sulzer D.; Casella L.; Zecca L.
Neuromelanin of the Human Substantia Nigra: An Update
(2014) in Neurotoxicity resarch
Segura-Aguilar J.; Paris I.; Muñoz P.; Ferrari E.; Zecca L.; Zucca F.A.
Protective and toxic roles of dopamine in Parkinson's disease
(2014) in Journal of neurochemistry
Ferrari E.; Capucciati A.; Monzani E.; Sturini M.; Girotto S.; Zucca F.A.; Bubacco L.; Zecca L.; Casella L.
Synthetic models of neuromelanin with fibrillated protein in the core
(2014) FENS 2014 - NTS Satellite Symposium, Baveno, Italy, July, 10th-11th, 2014
Tabuchi K.; Tanaka H.; Ojika M.; Zucca F.A.; Zecca L.; Ito S.; Wakamatsu K.
Convenient Synthetic Method Of Putative Degradative Markers To Identify Various Catecholic Metabolites In Addition To Dopamine And Norepinephrine Incorporated In Neuromelanin.
(2014) IPCC 2014 - XXII International Pigment Cell Conference, Singapore, September 4 - 7, 2014
Capucciati A.; Ferrari E.; Monzani E.; Sturini M.; Girotto S.; Zucca F.A.; Bridelli M.G.; Bubacco L.; Zecca L.; Casella L.
Melanin-protein fibrils conjugates as models to study neuromelanin structure and reactivity.
(2014) Zing Conference on Oxidative Stress, Parador de Oropesa, Spain, October 3 - 6, 2014
Cassani, E.; Barichella, M.; Cilia, R.; Akpalu, A.; Ofosu-Budu, K.; Cham, M.; Ferrario, E.; Faceli, E.; Zecca, L.; Sparvoli, F.; Privitera, G.; De Marco, P.; Zecchinelli, A.; Bonetti, A.; Iorio, L.; Amboni, M.; Cereda, E.; Pezzoli, G.
Mucuna pruriens: A new strategy for Parkinson's disease treatment in Africa. An update
(2014) 18th International Congress of Parkinson's Disease and Movement Disorders, Stockholm, Sweden, June 08 - 12, 2014
Cebrian C.; Zucca F.A.; Zecca L.; Loike J.D.; Sulzer D.
NEURONAL MHC-I DISPLAY IN T-CELL MEDIATED NEURODEGENERATION
(2013) Dopamine 2013, Alghero, Italy, May 24 - 28, 2013
Zecca L.; Bellei C.; Ferrari E.; Bubacco L.; Casella L.; Zucca F.A.
NEUROMELANINS ACCUMULATE IN NEURONS DURING HUMAN BRAIN AGING AND BIND METALS
(2013) Biomet 13 - XIII Workshop on PharmacoBioMetallics, Catania (Italy), October 25 and 26, 2013
Wakamatsu K.; Tabuchi K.; Tanaka H.; Zucca F.A.; Zecca L.; Ito S.
Elaboration of chemical degradative approach to characterizing neuromelanins form various brain regions
(2013) the 25th annual meeting of the Japanese society for Pigment Cell Research, Osaka University, Osaka, Japan, November 16-17 2013
Zecca L.; Cebrián C.; Vanna R.; Bellei C.; De Palma A.; Mauri P.; Casella L.; Zucca F.A.; Sulzer D.
NEUROMELANIN ORGANELLES PATHWAYS AND NEURODEGENERATION IN PARKINSON'S DISEASE
(2013) Dopamine 2013, Alghero, Italy, May 24 - 28, 2013
Zecca L.; Vanna R.; Bellei C.; De Palma A.; Di Silvestre D.; Mauri P.; Sulzer D.; Casella L.; Zucca F.A.
NEUROMELANIN ORGANELLES AND AUTOPHAGY IN BRAIN AGING
(2013) VI Neurotoxicity Meeting: Mechanisms for neurodegenerative disorders, Valdivia, Chile, March 21 - 24, 2013
Zhang W.; Zecca L.; Wilson B.; Ren H.W.; Wang Y.J.; Wang X.M.; Hong J.S.
Human neuromelanin: an endogenous microglial activator for dopaminergic neuron death.
(2013) in Frontiers in bioscience (Elite ed. Online)
Ferrari E.; Engelen M.; Monzani E.; Sturini M.; Girotto S.; Bubacco L.; Zecca L.; Casella L.
Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis.
(2013) in JBIC. Journal of biological inorganic chemistry (Print)
Zecca L.; Cupaioli F.A.; Bellei C.; Ferrari E.; Mauri P.; Sulzer D.; Zucca F.A.
Neuromelanin organelle pathways in aging and neurodegeneration of Parkinson's Disease
(2013) Annual Meeting of the CNR Aging program 2012-2014 during "9th Congress of the European Union Geriatric Medicine Society - EUGMS", Lido di Venezia, Italy, October 2-4, 2013
Cebrian C.; Zucca F.A.; Zecca L.; Loike J.D.; Sulzer D.
NEURONAL MHC-I DISPLAY IN T-CELL MEDIATED NEURODEGENERATION
(2013) Molecular Neurodegeneration - Basic biology and disease pathways, Cannes, France, September 10 - 12, 2013
Cebrián C.; Zucca F.A.; Zecca L.; Loike J.D.; Sulzer D.
A ROLE FOR NEURONAL MHC-I DISPLAY BY IN PARKINSON'S DISEASE?
(2012) The Tenth International Catecholamine Symposium, Pacific Grove, California, USA, September 9-13, 2012
Bachis A.; Avdoshina V.; Zecca L.; Parsadanian M.; Mocchetti I.
Human immunodeficiency virus type 1 alters brain-derived neurotrophic factor processing in neurons
(2012) in The journal of neuroscience (Online)
Wakamatsu K.; Murase T.; Zucca F.A.; Zecca L.; Ito S.
Biosynthetic pathway to neuromelanin and its aging process
(2012) in Pigment cell & melanoma research (Print)
Engelen M.; Vanna R.; Bellei C.; Zucca F.A.; Wakamatsu K.; Monzani E.; Ito S.; Casella L.; Zecca L.
Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure
(2012) in PloS one
Zecca L.; Zhang W.; Jackson-Lewis V.; Przedborski S.; Hong J.S.; Sulzer D.; Bellei C.; Casella L.; Turro N.J.; Eisner M.; Crippa P.R.; Ito S.; Wakamatsu K.; Simon J.D.; Zucca F.A.
Neuromelanins in brain aging and Parkinson's disease.
(2011) IPCC 2011, "Skin and Other Pigment Cells: Bridging Clinical Medicine and Science", Bordeaux, France, September 21-24, 2011
Wakamatsu K.; Murase T.; Zucca F.A.; Zecca L.; Ito S.
Chemistry and biophysics of melanins
(2011) IPCC 2011 - "Skin and Other Pigment Cells: Bridging Clinical Medicine and Science", Bordeaux, France, September 21-24, 2011
Zhang W.; Phillips K.; Wielgus A.R.; Liu J.; Albertini A.; Zucca F.A.; Faust R.; Qian S.Y.; Miller D.S.; Chignell C.F.; Wilson B.; Jackson-Lewis V.; Przedborski S.; Joset D.; Loike J.; Hong J.S.; Sulzer D.; Zecca L.
Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson's Disease
(2011) in Neurotoxicity resarch
Cebrián C.; Loike JD; Zucca F.A.; Zecca L.; Sulzer D.
EXPRESSION OF MHC-I ON SUSBTANTIA NIGRA AND LOCUS COERULEUS OF HUMAN CONTROL and PARKINSON'S DISEASE SUBJECTS: IMPLICATIONS IN DOPAMINERGIC NEURONAL DEGENERATION
(2011) "Society for Neuroscience", Washington, DC, USA, November 12-16, 2011
Zecca L, Bellei C, Cupaioli FA, Zucca FA
Protective and neurotoxic role of neuromelanin in human brain
(2010) COST Action D34, Final Meeting, Firenze
Zhang W, Phillips K, Albertini A, Cupaioli FA, Zucca FA, Faust R, Jackson-Lewis V, Przedborski S, Loike J, Hong JS, Sulzer D, Zecca L.
Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease.
(2010) Oxidative Stress and Neurodegenerative Diseases Joint Workshop of the COST Actions D34 and B35, Lisbon
Luo L.; Rodriguez E.; Jerbi K.; Lachaux J.P.; Martinerie J.; Corbetta M.; Shulman G.L.; Piomelli D.; Turrigiano G.G.; Nelson S.B.; Joëls M.; de Kloet E.R.; Holsboer F.; Amodio D.M.; Frith C.D.; Block M.L.; Zecca L.; Hong J.S.; Dantzer R.; Kelley K.W.; Bud Craig A.D.
Ten years of Nature Reviews Neuroscience: insights from the highly cited
(2010) in Nature reviews. Neuroscience (Online)
Tousi N.S.; Buck D.J.; Zecca L.; Davis R.L.
Neuromelanin inhibits CXCL10 expression in human astroglial cells
(2010) in Neuroscience letters (Print)
Crippa P.R.; Eisner M.; Morante S.; Stellato F.; Vicentin F.C.; Zecca L.
An XAS study of the sulfur environment in human neuromelanin and its synthetic analogs.
(2010) in European biophysics journal
Zecca L. , Zucca F.A., Jackson-Lewis V., Przedborski S., Hong J.S., Sulzer D.
The role of neuromelanin in brain aging and neurodegeneration of Parkinson's disease
(2009) IV Neurotoxicity Society Meeting:Neurochemical Mechanisms for Neurodegenerative Disorders, Arica, Chile
Zhang W., Phillips K., Wielgus A.R., Liu J., Albertini A., Zucca F.A., Faust R., Qian S.Y., Miller D.S., Chignell C.F., Wilson B., Jackson-Lewis V., Przedborski S., Joset D., Loike J., Hong J.S., Sulzer D., Zecca L.
Neuromelanin activates microglia and induces substantia nigra neuron death. A key mechanism of Parkinson's disease.
(2009) 9th International Conference on Alzheimer's & Parkinson's Diseases 2009, Prague, Czech Republic
Zecca L., Bellei C., Cupaioli F.A., Albertini A., Casella L., Bergamaschi L., Turro N.J., Eisner M., Ito S., Wakamatsu K., Simon J.D., Zucca F.A.
Melanic Pigments in the Human brain
(2009) 15th Meeting of the European Society for Pigment Cell Research, Münster, Germany
Ward W.C.; Zucca F.A.; Bellei C.; Zecca L.; Simon J.D.
Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids.
(2009) in Archives of biochemistry and biophysics (Print)
Bush W.D.; Garguilo J.; Zucca F.A.; Bellei C.; Nemanich R.J.; Edwards G.S.; Zecca L.; Simon J.D.
Neuromelanins Isolated from Different Regions of the Human Brain Exhibit a Common Surface Photoionization Threshold
(2009) in Photochemistry and photobiology
Hegde M.L.; Bharathi P.; Suram A.; Venugopal C.; Jagannathan R.; Poddar P.; Srinivas P.; Sambamurti K.; Rao K.J.; Scancar J.; Messori L.; Zecca L.; Zatta P.
Challenges associated with metal chelation therapy in Alzheimer's disease.
(2009) in Journal of Alzheimer's disease
Engelen M., Vanna R., De Palma A., Cupaioli F.A., Bellei C., Zucca F.A., Mauri P.L., Zecca L.
Proteomic profile of neuromelanin and neuromelanin-containing organelles
(2009) 5th Congress of the Portuguese Proteomics Network - ProCura - 1st International Congress on Analytical Proteomics ICAP, Caparica, Portugal
Zecca L.; Zhang W.; Phillips K.; Albertini A.; Zucca F.A.; Faust R.; Loike J.; Hong J.S.; Sulzer D.
Neuromelanin activates microglia and induces substantia nigra neuron death.
(2008) Meeting FIRB 2008 - Metodologie e Tecnologie Innovative per la Farmaceutica, Lecce, Italy,, March 13-14, 2008
Sulzer D.; Mosharov E.; Talloczy Z.; Zucca F.A.; Simon J.D.; Zecca L.
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
(2008) in Journal of neurochemistry
Zecca L.; Wilms H.; Geick S.; Claasen J.H.; Brandenburg L.O.; Holzknecht C.; Panizza M.L.; Zucca F.A.; Deuschl G.; Sievers J.; Lucius R.
Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease
(2008) in Acta neuropathologica
Zecca L.; Casella L.; Albertini A.; Bellei C.; Zucca F.A.; Engelen M.; Zadlo A.; Szewczyk G.; Zareba M.; Sarna T.
Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease
(2008) in Journal of neurochemistry
Zecca L.; Bellei C.; Costi P.; Albertini A.; Monzani E.; Casella L.; Gallorini M.; Bergamaschi L.; Moscatelli A.; Turro N.J.; Eisner M.; Crippa P.R.; Ito S.; Wakamatsu K.; Bush W.D.; Ward W.C.; Simon J.D.; Zucca F.A.
New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals
(2008) in Proceedings of the National Academy of Sciences of the United States of America
Ward W.; Guan Z.; Zucca F.A.; Zecca L.; Simon J.D.
Mapping the lipids in isolated neuromelanin and neuromelanin-containing tissues from normal and Parkinson's diseased subjects: Identification of novel dolichoic acid.
(2007) 14th Congress of European Society for Pigment Cell Research (ESPCR-2007), Bari, Italy,, October 14-17, 2007
Zecca L.; Bellei C.; Panizza M.; Gallorini M.; Bergamaschi L.; Sulzer D.; Simon J.D.; Zucca F.A.
Neuromelanin and metals in brain aging and neurodegeneration.
(2007) 14th Congress of European Society for Pigment Cell Research (ESPCR-2007), Bari, Italy, October 14-17, 2007
Rao K.S.J.; Zucca F.A.; Bellei C.; Panizza M.; Zecca L.
Amyloid beta and neuromelanin - Toxic or protective molecules? The cellular context makes the difference.
(2007) 2nd European Conference on Chemistry for Life Sciences, Wroclaw, Poland, September 4-8, 2007
Faust R.; Phillips K.; Albertini A.; Zucca F.A.; Joset D.; Loike J.; Sulzer D.; Zecca L.
Activation of microglia by neuromelanin: correlation of neuromelanin phagocytosis and degradation, reactive oxygen species production, and ventral midbrain neuron death.
(2007) Dopamine 50 years, Goteborg, Sweden, May 30-June 2, 2007
Rao K.S.J.; Hegde M.L.; Anitha S.; Musicco M.; Zucca F.A.; Turro N.J.; Zecca L.
Amyloid beta and neuromelanin - Toxic or protective molecules? The cellular context makes the difference.
(2007) 8th International Conference AD/PD 2007, Salzburg, Austria, March 14-18, 2007
Zecca L.; Giannelli S.; Bellei C.; Panizza M.; Fariello R.G.; Gallorini M.; Bergamaschi L.; Sulzer D.; Hong J.S.; Zucca F.A.
Neuromelanin and metals in brain aging and neurodegeneration.
(2007) IIIrd Neurotoxicity Society Meeting Neurochemical Mechanisms for Neurodegenerative Disorders, Pucon, Chile, March 23-25, 2007
Sathyanarayana Rao T.S.; Zecca L.; Rao K.J.
Tracemetals, neuromelanin and neurodegeneration: An interesting area for research.
(2007) in Indian Journal of Psychiatry
Ward W.C.; Guan Z.; Zucca F.A.; Fariello R.G.; Kordestani R.; Zecca L.; Raetz C.R.; Simon J.D.
Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain
(2007) in Journal of lipid research (Print)
Block M.L.; Zecca L.; Hong J.S.
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
(2007) in Nature reviews. Neuroscience (Online)
Wilms H.; Zecca L.; Rosenstiel P.; Sievers J.; Deuschl G.; Lucius R.
Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications
(2007) in Current pharmaceutical design (Print)
Zecca L.; Giannelli S.; Bellei C.; Albertini A.; Gallorini M.; Giaveri G.; Fariello R.G.; Sulzer D.; Zucca F.A.
The role of neuromelanin in brain aging and Parkinson's disease.
(2006) World Parkinson Congress, Washington, District of Columbia, USA, February 22-26, 2006
Zecca L.; Giannelli S.; Bellei C.; Panizza M.; Albertini A.; Gallorini M.; Fariello R.G.; Zucca F.A.; Hong J.S.; Sulzer D.
The role of neuromelanin in brain aging and Parkinson's disease.
(2006) IVth International Symposium on Metals, Environment and Health, Szklarska Poreba, Poland, September 6-10, 2006
Rao K.S.; Hegde M.L.; Anitha S.; Musicco M.; Zucca F.A.; Turro N.J.; Zecca L.
Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference.
(2006) in Progress in neurobiology (Print)
Zucca F.A.; Bellei C.; Giannelli S.; Terreni M.R.; Gallorini M.; Rizzio E.; Pezzoli G.; Albertini A.; Zecca L.
Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability.
(2006) in Journal of neural transmission
Zecca L.; Zucca F.A.; Albertini A.; Rizzio E.; Fariello R.G.
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease
(2006) in Neurology
Bush W.D.; Garguilo J.; Zucca F.A.; Albertini A.; Zecca L.; Edwards G.S.; Nemanich R.J.; Simon J.D.
The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.
(2006) in Proceedings of the National Academy of Sciences of the United States of America
Zecca L.; Giannelli S.; Panizza M.; Bellei C.; Albertini A.; Phillips K.; Sulzer D.; Zucca F.A.
The role of neuromelanin in brain aging and Parkinson's disease.
(2006) XXIst International Winter Meeting st. Moritz onGrowth and death in the nervous system, St. Moritz, Switzerland, March 22-26, 2006
Bush W.D.; Simon J.D.; Zucca F.A.; Zecca L.; Gargulio J.; Nemanich R.J.; Edwards G.
A modern imaging investigation of neuromelanin extracted from the substantia nigra region of the human brain.
(2005) 19th International Pigment Cell Conference, Reston, Virginia, USA, September 18-22, 2005
Zucca F.A.; Bellei C.; Giannelli S.; Toscani M.; Gallorini M.; Giaveri G.; Arosio P.; Fariello R.G.; Turro N.; Hornykiewicz O.; Zecca L.
The relevance of low iron, high ferritin and high neuromelanin to neuronal vulnerability in parkinsonian syndromes.
(2005) Gordon Research Conferences on Catecholamines (Proctor Academy), Andover, New Hampshire, USA, July 24-29, 2005
Zecca L.; Bellei C.; Giannelli S.; Gallorini M.; Fariello R.G.; Sulzer D.; Zucca F.A.
Neuromelanin in the human brain: protective and toxic role.
(2005) 19th International Pigment Cell Conference, Reston, Virginia, USA, September 18-22, 2005
Zecca L.; Giannelli S.; Bellei C.; Albertini A.; Gallorini M.; Giaveri G.; Fariello R.G.; Sulzer D.; Zucca F.A.
The role of neuromelanin and iron in brain aging and Parkinson's disease.
(2005) 2nd Meeting on Molecular Mechanisms of Neurodegeneration (Universita' degli Studi di Milano), Milano, Italy, May 7-10, 2005
L. Zecca.; M. Toscani.; C. Bellei.; M. Gallorini.; R.G. Fariello.; F.A. Zucca.
Neuromelanin in human brain: protective and toxic role.
(2005) 7th International Conference AD/PD 2005, Sorrento, Italy, March 9-13, 2005
Zecca L.; Giannelli S.; Bellei C.; Gallorini M.; Giaveri G.; Fariello R.G.; Zucca F.A.
Neuromelanin a chelator of iron and other metals in catecholaminergic neurons of substantia nigra and locus coeruleus.
(2005) 7th Neurochemistry Winter Conference, Sölden, Austria, April 2-8, 2005
Zecca L.
The interaction of Neuromelanin with metals and its role in neurodegeneration
(2005) 161ST Meeting of the committee of senior officials for scientific and technical research (COST), Brussels, Belgium, March 15-16, 2005
Gupta V.B.; Anitha S.; Hegde M.L.; Zecca L.; Garruto R.M.; Ravid R.; Shankar S.K.; Stein R.; Shanmugavelu P.; Jagannatha Rao K.S.
Aluminium in Alzheimer's disease: are we still at a crossroad?
(2005) in Cellular and molecular life sciences (Print. ed.)
Zecca L, Berg D, Arzberger T, Ruprecht P, Rausch WD, Musicco M, Tampellini D, Riederer P, Gerlach M, Becker G
In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage
(2005) in Movement disorders
Zucca F.A.; Bellei C.; Giannelli S.; Toscani M.; Gallorini M.; Giaveri G.; Arosio P.; Santambrogio P.; Fariello R.G.; Zecca L.
Low iron, high ferritin and high neuromelanin in locus coeruleus neurons. A biochemical profile with relevance to neuronal vulnerability in parkinsonian syndromes
(2005) 16th International Congress on Parkinson´s Disease and Related Disorders, Berlin, Germany, June 5-9, 2005
Zucca F.A.; Bellei C.; Giannelli S.; Toscani M.; Gallorini M.; Giaveri G.; Arosio P.; Fariello R.G.; Turro N.; Hornykiewicz O.; Zecca L.
The relevance of low iron, high ferritin and high neuromelanin to neuronal vulnerability in parkinsonian syndromes.
(2005) 7th International Conference AD/PD 2005, Sorrento, Italy, March 9-13, 2005
Zucca F.A.; Bellei C.; Giannelli S.; Toscani M.; Gallorini M.; Giaveri G.; Arosio P.; Fariello R.G.; Turro N.; Hornykiewicz O.; Zecca L.
The relevance of low iron, high ferritin and high neuromelanin to neuronal vulnerability in parkinsonian syndromes.
(2005) Gordon Research Conferences on Catecholamines (Proctor Academy), Andover, New Hampshire, USA, July 24-29, 2005
Zecca L.; Costi P.; Piva F.; Dondi D; Zucca F.A.
Effetti dell'esposizione cronica a CEM di 50 Hz su neurotrasmettitori e recettori nel cervello di ratto
(2004) 3° Convegno Nazionale - Interazione tra campi elettromagnetici e soggetti esposti, Roma, italia, 1-2 Aprile 2004
Zecca L.; Toscani M.; Bellei C.; Costi P.; Gallorini M.; Rizzio E.; Giaveri G.; Zucca F.A.
Iron and copper molecules in aging of human substantia nigra. Consequences for neurodegenerative processes.
(2004) 6th Neurochemistry Winter Conference, Soelden, Oetztal, Austria, March 27-April 1, 2004
Zecca L.; Stroppolo A.; Toscani M.; Bellei C.; Gallorini M.; Giaveri G.; Arosio P.; Fariello R.G.; Turro N.; Hornykiewicz O.; Zucca F.A.
Low iron, high ferritin and high neuromelanin in locus coeruleus neurons. A biochemical profile with relevance to neuronal vulnerability in parkinsonian syndromes.
(2004) Mental Dysfunction in Parkinson's Disease, Salzburg, Austria, October 24-27, 2004
Zecca L.
Is neuromelanin of substantia nigra protective or toxic for neurons?
(2004) The Movement Disorder Society - 8th International Congress of Parkinson's Disease and Movement Disorders, Rome, Italy, 13-17 June, 2004
Zecca L.
Is neuromelanin of substantia nigra protective or toxic for neurons?
(2004) The Global College of Neuroprotection and Neuroregeneration 2004, Zermatt, Switzerland, February 8-10, 2004
Zecca L.; Stroppolo A.; Gatti A.; Tampellini D.; Toscani M.; Gallorini M.; Giaveri G.; Arosio P.; Santambrogio P.; Fariello R.G.; Karatekin E.; Kleinman M.H.; Turro N.; Hornykiewicz O.; Zucca F.A.
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging.
(2004) in Proceedings of the National Academy of Sciences of the United States of America
Shamoto-Nagai M.; Maruyama W.; Akao Y.; Osawa T.; Tribl F.; Gerlach M.; Zucca F.A.; Zecca L.; Riederer P.; Naoi M.
Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells
(2004) in Journal of neural transmission
Zecca L.; Youdim M.B.H.; Riederer P.; Connor J.R.; Crichton R.R.
Iron, brain ageing and neurodegenerative disorders.
(2004) in Nature reviews. Neuroscience (Online)
Zucca F.A.; Giaveri G.; Gallorini M.; Albertini A.; Toscani M.; Pezzoli G.; Lucius R.; Wilms H.; Sulzer D.; Ito S.; Wakamatsu K.; Zecca L.
The Neuromelanin of Human Substantia Nigra: Physiological and Pathogenic Aspects
(2004) in Pigment cell research
Quaglino D.; Capri M.; Zecca L.; Franceschi C.; Ronchetti I.P.
The effect on rat thymocytes of the simultaneous in vivo exposure to 50-Hz electric and magnetic field and to continuous light
(2004) in TheScientificWorldjournal
Zecca L.; Zucca F.A.; Toscani M.; Rizzio E.; Giaveri G.; Bergamaschi L.; Profumo A.; Groppi F.; Bonardi M.; Gallorini M.
The application of the Neutron Activation Analysis for trace metals determination in human brain tissues and substantia nigra neuromelanin.
(2004) 11th International conference "Modern Trends in Activation Analysis", (University of Surrey) Guildford, UK, June 20-25, 2004
Zecca L.; Zucca F.A.; Fariello R.; Gallorini M.; Sulzer D.; Rosenstiel P.; Lucius R.; Wilms H.
Is neuromelanin of substantia nigra protective or toxic for neurons?
(2003) 6th International Conference AD/PD 2003, Seville, Spain, May 8-12, 2003
Zecca L.; Zucca F.A.; Giaveri G.; Rizzio E.; Gallorini M.
Iron, copper and zinc concentration in substantia nigra of human brain during aging.
(2003) 6th International conference on methods and applications of radioanalytical chemistry-MARC VI, Kailua-Kona, Hawaii, USA, April 7-11, 2003
Zecca L.; Costi P.; Zucca F.A.; Sulzer D.; Rosenstiel P.; Lucius R.; Wilms H.
The behavior of substantia nigra neuromelanin in normal aging and Parkinson's disease.
(2003) 5th Neurochemistry Winter Conference 2003, Sölden, Ötztal, Austria, April 5-10, 2003
Double K.L., Gerlach M., Schunemann V., Trautwein A.X., Zecca L., Gallorini M., Youdim M.B., Riederer P., Ben-Shachar D.
Iron-binding characteristics of neuromelanin of the human substantia nigra.
(2003) in Biochemical pharmacology
Gerlach M.; Double K.L.; Ben-Shachar D.; Zecca L.; Youdim M.B.H.; Riederer P.
Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease.
(2003) in Neurotoxicity resarch
Wilms H.; Rosenstiel P.; Sievers J.; Deuschl G.; Zecca L.; Lucius R.
Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease.
(2003) in The FASEB journal
Zecca L.; Zucca F.A.; Costi P.; Tampellini D.; Gatti A.; Gerlach M.; Riederer P.; Fariello R.G.; Ito S.; Gallorini M.; Sulzer D.
The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour
(2003) in Journal of neural transmission. Supplementum
Canesi M.; Perbellini L.; Maestri L.; Silvani A.; Zecca L.; Bet L.; Pezzoli G.
Poor metabolization of n-hexane in Parkinson's disease.
(2003) in Journal of neurology (Print)
Wakamatsu K.; Fujikawa K.; Zucca F.A.; Zecca L.; Ito S.
The structure of neuromelanin as studied by chemical degradative methods
(2003) in Journal of neurochemistry
Zecca L.; Zucca F.A.; Wilms H.; Sulzer D.
Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics
(2003) in Trends in neurosciences (Regul. ed.)
Zucca F.A.; Toscani M.; Gallorini M.; Rizzio E.; Giaveri G.; Zecca L.
IRON, COPPER AND THEIR MOLECULES IN SUBSTANTIA NIGRA OF NORMAL SUBJECTS DURING AGING
(2003) Gordon Research Conferences on Catecholamines (The Queen's College), Oxford, England, August 3rd-8th, 2003
Zecca L.; Costi P.; Cerretelli P; Zucca F.A.
Effect of prolonged exposure to 50 Hz electric and magnetic fields on neurotransmitters in rat brain
(2002) Biological effects of EMFs, 2nd International Workshop, Rhodes, Greece, October 7-11, 2002
Zecca L.; Costi P.; Piva F.; Dondi D; Zucca F.A.
Effect on neurotransmitters and receptors in rat exposed to 50Hz electric and magnetic fields from conception to adult life
(2002) Biological effects of EMFs, 2nd International Workshop, Rhodes, Greece, October 7-11, 2002
Zecca L.; Berg D.; Ruprecht P.; Rausch W.D.; Arzberger T.; Musicco M.; Tampellini D.; Riederer P.; Gerlach M.; Becker G.
The in vivo detection of iron and ferritins by transcranial sonography: A new approach for early diagnosis of Parkinson's disease
(2002) 7th International Congress of Parkinson's Disease and Movement Disorders, Miami, Florida, USA, November 10-14, 2002
Zecca L.
Neuromelanin and metals in brain aging and parkinson's disease
(2002) The 2nd International Conference on Metals and the Brain, Fez, Maroc, September 25-28, 2002
Zecca L.; Fariello R.; Riederer P.; Sulzer D.; Gatti A.; Tampellini D.
The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
(2002) in FEBS letters (Print)
Double K.; Ben-Shachar D.; Youdim M.; Zecca L.; Riederer P.; Gerlach M.
Influence of neuromelanin on oxidative pathways within the human substantia nigra
(2002) in Neurotoxicology and teratology
Zecca L.; Tampellini D.; Gatti A.; Crippa R.; Eisner M.; Sulzer D.; Ito S.; Fariello R.; Gallorini M.
The neuromelanin of human substantia nigra and its interaction with metals
(2002) in Journal of neural transmission
Anitha, S; Shanmugavelu, P; Gazula, VR; Shankar, SK; Menon, RB; Rao, RV; Rao, JKS; Zecca, L
Molecular understanding of aluminum bioinorganic chemistry in relevance to the pathology of Alzheimer's disease
(2002) in , 2002
Zecca L.; Berg D.; Ruprecht P.; Rausch W-D.; Arzberger T.; Musicco M.; Gatti A.; Tampellini D.; Zucca F.A.; Riederer P.; Becker G.; Gerlach M.
The in vivo detection of iron and neuromelanin by Transcranial Sonography: a potential approach for early diagnosis of Parkinson's Disease
(2002) Telethon Convention, Riva del Garda, Italy, November 24-24, 2002
Zecca L.; Costi P.; Gallorini M.; Tampellini D.
Substantia nigra neuromelanin: structure, synthesis, molecular behavior and age trend
(2001) 3rd Neurochemistry Winter Conference, Sölden, Austria, March 17-22, 2001
Zecca L.; Gallorini M.; Schunemann V.; Trautwein A.X.; Gerlach M.; Riederer P.; Vezzoni P.; Tampellini D.
Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes.
(2001) in Journal of neurochemistry
Reif A.; Zecca L.; Riederer P.; Feelisch M.; Schmidt H.H.
Nitroxyl oxidizes NADPH in a superoxide dismutase inhibitable manner.
(2001) in Free radical biology & medicine
Berg D.; Gerlach M.; Youdim M.B.H.; Double K.L.; Zecca L.; Riederer P.; Becker G.
Brain iron pathways and their relevance to Parkinson's disease.
(2001) in Journal of neurochemistry
Zecca L.; Tampellini D.; Costi P.; Rizzio E.; Giaveri G.; Gallorini M.
Combined biochemical separation and INAA for the determination of iron and other metals in Neuromelanin of human brain Substantia Nigra
(2001) in Journal of radioanalytical and nuclear chemistry (Print)
Zecca L.; Tampellini D.; Gerlach M.; Riederer P.; Fariello R.G.; Sulzer D.
Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour
(2001) in MP. Molecular pathology
Zecca L.; Tampellini D.; Rizzio E.; Giaveri G.; Gallorini M.
The determination of iron and other metals by INAA in Cortex, Cerebellum and Putamen of human brain and in their neuromelanins
(2001) in Journal of radioanalytical and nuclear chemistry (Print)