Marco Severgnini

The information published in this page are entirely managed by MARCO SEVERGNINI who is completely responsible for it.

He started working in scientific research dealing with the development of deposition protocols and data analysis of low / medium density custom microarrays for genotyping analysis. Currently, he is working as a senior bioinformatician in the Genomics group of the Institute of Biomedical Technologies, with particular reference to the analysis of data from high-throughput sequencing (NGS)

Interest areas:
  • Microbiota analysis in physiological / pathological states and interaction with the host
  • Analysis of genomic structural rearrangements
  • Analysis of short-tandem repeats

Contacts

Phone: +39 02 26422705
Address: via f.lli Cervi, 93, Segrate (MI), Italy

International Ids

Scopus Author ID: 12798920900
WoS Researcher ID: F-5832-2013
Google Scholar: C-hw6ZEAAAAJ

H-indexes

Google Scholar H-Index: 29
Scopus H-Index: 25
ISI-WoS H-Index: 23

Experience

Full-time researcher
Company: CNR - Consiglio Nazionale delle Ricerche - via fratelli Cervi, 93, Segrate (MI)
Company web site: http://www.itb.cnr.it
Time period: 12/2009 - today
  • Bioinformatic analysis of Next Generation Sequencing data in the field of complex ecosystems characterization (human gut microbiota in adult and infants, in healthy and diseased subjects)
  • Bioinformatic analysis of Next Generation Sequencing data in determining structural variants in tumors (acute lymphoblastic leukemia in children, acut myeloid leukemia)
  • Bioinformatic analysis of Next Generation Sequencing data on retroviral integration (HIV, ASLV, MLV)

Non-permanent research position
Company: CNR - Consiglio Nazionale delle Ricerche - via fratelli Cervi, 93, Segrate (MI)
Company web site: http://www.itb.cnr.it
Time period: 04/2008 - 12/2009
  • Implementation of microarray platforms for characterization of complex ecosystems (human gut microbiota) and for food safety ( pathogendetection in milk or seafood samples)
  • Bionformatic analysis of Next Generation Sequencing data for mutation detection in human genetic diseases (dystrophin, colon cancer)

Fellow
Company: CNR - Consiglio Nazionale delle Ricerche - via fratelli Cervi, 93, Segrate (MI)
Company web site: http://www.itb.cnr.it
Time period: 11/2006 - 03/2008
  • Implementation of microarray-based DNA molecular techniques and related statistical analyses
  • Development of integrated lab-on-chip platforms for genotyping analysis
  • High-density microarray data analysis, in the field of differential expression

Research fellow
Company: CNR - Consiglio Nazionale delle Ricerche - via fratelli Cervi, 93, Segrate (MI)
Company web site: http://www.itb.cnr.it
Time period: 02/2004 - 10/2006
  • Application of Design of Experiments (DOE) methods for qualitative control and improvement of various molecular biology protocols
  • Opimization of microarray production methods
  • Statistical analysis of microarray data, with a particular focus on low/medium density genotyping


Activities

Teamworks, commissions or organisms

Consiglio d'Istituto ITB-CNR
Related working experience: Full-time researcher
Role: Member
Participation time period: 07/2017 - today
Involved organizations: ITB - ISTITUTO DI TECNOLOGIE BIOMEDICHE;

Tutor

Caratterizzazione del microbiota del tratto gastrointestinale nella malattia di Parkinson tramite analisi bioinformatica di dati metagenomici
Related working experience: Full-time researcher
Role: External tutor
Participation time period: 10/2015 - 09/2016
Involved organizations: ITB - ISTITUTO DI TECNOLOGIE BIOMEDICHE; UNIMI - DIPARTIMENTO DI BIOSCIENZE;


Education

Laurea in Ingegneria Biomedica (vecchio ordinamento)
Politecnico di Milano - piazza Leonardo da Vinci, 32, Milano
Grade: 93/100
Graduation date: 2003-12-19
Attendance time period: 09/1997 - 12/2003
Thesis: Applicazione dei metodi di Taguchi all'analisi del processo di fabbricazione di DNA microarrays

Esame di stato per l'abilitazione all'esercizio della professione di Ingegnere
Politecnico di Milano - piazza Leonardo da Vinci, 32, Milano
Grade: 91/100


Research activities classification (ERC)

BIOINFORMATICS
GENETICS, GENOMICS, BIOINFORMATICS AND SYSTEMS BIOLOGY: GENETICS, POPULATION GENETICS, MOLECULAR GENETICS, GENOMICS, TRANSCRIPTOMICS, PROTEOMICS, METABOLOMICS, BIOINFORMATICS, COMPUTATIONAL BIOLOGY, BIOSTATISTICS, BIOLOGICAL MODELLING AND SIMULATION, SYSTEMS BIOLOGY, GENETIC EPIDEMIOLOGY
GENOMICS, COMPARATIVE GENOMICS, FUNCTIONAL GENOMICS
LIFE SCIENCES
TRANSCRIPTOMICS

Skills

BIOINFORMATICA
DNA MICROARRAYS
MICROBIOMA
SEQUENZIAMENTO ULTRAMASSIVO

Curriculum Vitae


Research products

Andrea Baragetti , Marco Severgnini , Elena Olmastroni , Carola Conca Dioguardi , Elisa Mattavelli , Andrea Angius , Luca Rotta , Javier Cibella , Giada Caredda , Clarissa Consolandi , Liliana Grigore , Fabio Pellegatta , Flavio Giavarini , Donatella Caruso , Giuseppe Danilo Norata , Alberico Luigi Catapano and Clelia Peano

Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis

Andrea Baragetti , Marco Severgnini , Elena Olmastroni , Carola Conca Dioguardi , Elisa Mattavelli , Andrea Angius , Luca Rotta , Javier Cibella , Giada Caredda , Clarissa Consolandi , Liliana Grigore , Fabio Pellegatta , Flavio Giavarini , Donatella Caruso , Giuseppe Danilo Norata , Alberico Luigi Catapano (2021) in Nutrients
Tolomeo, Doron; Agostini, Antonio; Macchia, Gemma; L'Abbate, Alberto; Severgnini, Marco; Cifola, Ingrid; Frassanito, Maria Antonia; Racanelli, Vito; Solimando, Antonio Giovanni; Haglund, Felix; Mertens, Fredrik; Storlazzi, Clelia Tiziana

BL1391: an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features

(2021) in Human cell
Federica Prinelli, Nithiya Jesuthasan, Marco Severgnini, Massimo Musicco, Fulvio Adorni, Maria Lea Correa Leite, Chiara Crespi, Sara Bernini.

Exploring the relationship between Nutrition, gUT microbiota, and BRain AgINg in community-dwelling seniors: the Italian NutBrain population-based cohort study protocol

(2020) in BMC geriatrics (Online)
Cremonesi, Paola; Morandi, Stefano; Ceccarani, Camilla; Battelli, Giovanna; Castiglioni, Bianca; Cologna, Nicola; Goss, Andrea; Severgnini, Marco; Mazzucchi, Massimiliano; Partel, Erika; Tamburini, Alberto; Zanini, Lucio; Brasca, Milena

Raw Milk Microbiota Modifications as Affected by Chlorine Usage for Cleaning Procedures: The Trentingrana PDO Case

(2020) in Frontiers in microbiology
van der Houwen, Tim B.; van Laar, Jan A. M.; Kappen, Jasper H.; van Hagen, Petrus M.; de Zoete, Marcel R.; van Muijlwijk, Guus H.; Berbers, Roos-Marijn; Fluit, Ad C.; Rogers, Malbert; Groot, James; Hazelbag, C. Marijn; Consolandi, Clarissa; Severgnini, Marco; Peano, Clelia; D'Elios, Mario M.; Emmi, Giacomo; Leavis, Helen L.

Behcet's Disease Under Microbiotic Surveillance? A Combined Analysis of Two Cohorts of Behcet's Disease Patients

(2020) in Frontiers in immunology
Lopetuso, Loris Riccardo; Severgnini, Marco; Pecere, Silvia; Ponziani, Francesca Romana; Boskoski, Ivo; Larghi, Alberto; Quaranta, Gianluca; Masucci, Luca; Ianiro, Gianluca; Camboni, Tania; Gasbarrini, Antonio; Costamagna, Guido; Consolandi, Clarissa; Cammarota, Giovanni

Esophageal microbiome signature in patients with Barrett's esophagus and esophageal adenocarcinoma

(2020) in PloS one
Marangoni A, Ceccarani C, Camboni T, Consolandi C, Foschi C, Salvo M, Gaspari V, D'Antuono A, Belletti M, Re MC, Severgnini M.

Pharyngeal microbiome alterations during Neisseria gonorrhoeae infection

(2020) in PloS one
Paola Cremonesi1, Marco Severgnini2, Alicia Romanò3,4, Mario Luini3, Bianca Castiglioni1

Comparison among four different bacterial DNA extraction protocols for analysing milk metagenomics

(2019) 23° Congresso dell'Associazione per la Scienza e le Produzioni Animali (ASPA), Sorrento, Italy, 11/06/2019, 14/06/2019
Ceccarani, Camilla; Foschi, Claudio; Parolin, Carola; D'Antuono, Antonietta; Gaspari, Valeria; Consolandi, Clarissa; Laghi, Luca; Camboni, Tania; Vitali, Beatrice; Severgnini, Marco; Marangoni, Antonella

Diversity of vaginal microbiome and metabolome during genital infections

(2019) in Scientific reports (Nature Publishing Group)
Elisa Borghi, PhD,1 Valentina Massa, PhD,1 Marco Severgnini, PhD,2 Grazia Fazio, PhD,3 Laura Avagliano, MD,1 Elena Menegola, PhD,4 Gaetano Pietro Bulfamante, MD,1 Giulia Morace, PhD,1 and Francesca Borgo, PhD1

Antenatal Microbial Colonization of Mammalian Gut

(2019) in Reproductive sciences (Thousand Oaks, Calif.)
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