Nicoletta Nuzziello

The information published in this page are entirely managed by NICOLETTA NUZZIELLO who is completely responsible for it.

In 2013, Nicoletta Nuzziello received the master's degree in Cellular and Molecular Biology at the University of Bari where she also obtained the Ph.D. in "Biomolecular, Pharmaceutical and Medical Sciences - curriculum in Neuroscience" in 2018. In 2014, she was awarded a 2-year research fellowship from ITB-CNR regarding the identification of diagnostic, prognostic and therapeutic biomarkers in proliferative and neurodegenerative diseases, for the project "Development of Bioinformatics Infrastructures for OMICS applications in Biomedicine". Since November 2017 she works at the Institute of Biomedical Technologies of the CNR of Bari as postdoctoral research fellow.

Interest areas:

Molecular analysis in several neurodegenerative diseases (e.g. Spinal Muscular Atrophy, Amyotrophic Lateral Sclerosis, Multiple Sclerosis) at the omic levels: high-throughput next generation sequencing (HT-NGS) and microfluidic/nanofluidic qPCR approaches for high-density and high-throughput profiling of transcriptome and miRNome. Identification of circulating molecular biomarkers (microRNAs), microRNA-target gene networks, and key developmental pathways associated with several human diseases. Characterization of Extracellular Vesicles (Microvesicles and Exosomes) in human serum, plasma and cerebrospinal fluid. Characterization of cell-free RNA in human matrices.


Phone: 0805929677
Skype: nicoletta.nuzziello_1

International Ids


Google Scholar H-Index: 6
Scopus H-Index: 5
ISI-WoS H-Index: 5


Provvedimento di associatura con incarico di collaborazione
Company: ITB - Istituto di tecnologie biomediche
Time period: 06/2017 - 06/2018

Borsista CNR
Company: ITB - ITB - Sede secondaria di Bari
Time period: 02/2014 - 02/2016

Characterization of diagnostic/prognostic/therapeutic biomarkers in proliferative diseases

Postdoctoral research fellow
Company: ITB - ITB - Sede secondaria di Bari


Scientific projects

A multidisciplinary search of molecular markers associated with the response to treatment in adult Spinal Muscular Atrophy
Role: Membro
Participation time period: 06/2020 - today

Cognitive impairment in Pediatric Multiple Sclerosis: searching for biomarkers predictive of progression
Role: Membro
Participation time period: 03/2015 - 12/2017


Dottorato di Ricerca in Scienze Biomolecolari, Farmaceutiche e Mediche (XXX ciclo) - curriculum Neuroscienze applicate
Università degli Studi di Bari
Graduation date: 2018-03-27
Thesis: Integrated analysis of microRNA and mRNA expression profiles: an original strategy for uncovering complex networks in Pediatric Multiple Sclerosis

Corso di perfezionamento post-laurea in Biologia della Nutrizione
Università degli Studi di Bari
Graduation date: 2015-07-31
Thesis: Nutraceutica e Malattie Neurodegenerative

Biologia Cellulare e Molecolare
Università degli Studi di Bari
Grade: 110 c/110
Graduation date: 2013-07-24
Thesis: sCLU: un biomarcatore nel tumore tiroideo indeterminato?

Biologia Cellulare e Molecolare
Università degli Studi di Bari
Grade: 110 c/110
Graduation date: 2010-12-09
Thesis: Metodiche di studio morfologico e funzionale degli osteoclasti


Production Understanding
Written Oral Written Oral Notes
English - Full professional proficiency

Research products

Liguori M.; Nuzziello N.; Introna A.; Consiglio A.; Licciulli F.; D'Errico E.; Scarafino A.; Distaso E.; Simone I.L.

Corrigendum: Dysregulation of micrornas and target genes networks in peripheral blood of patients with sporadic amyotrophic lateral sclerosis (Frontiers in molecular neuroscience, (2018), 11, 10.3389/fnmol.2018.00288)

Nicoletta Nuzziello, Francesco Craig, Marta Simone, Arianna Consiglio, Flavio Licciulli, Lucia Margari, Giorgio Grillo, Sabino Liuni, Maria Liguori

Integrated analysis of microRNA and mRNA expression profiles reveals a complex interaction network in Attention Deficit Hyperactivity Disorder

(2019) in Brain sciences
Liguori M.; Nuzziello N.; Simone M.; Amoroso N.; Viterbo R.G.; Tangaro S.; Consiglio A.; Giordano P.; Bellotti R.; Trojano M.

Association between miRNAs expression and cognitive performances of Pediatric Multiple Sclerosis patients: A pilot study

(2019) in Brain and behavior
Nuzziello N.; Liguori M.

Seeking a standardized normalization method for the quantification of microRNA expression

(2019) in Muscle & nerve (Print)
Casalino G.; Castellano G.; Consiglio A.; Liguori M.; Nuzziello N.; Primiceri D.

A Predictive Model for MicroRNA Expressions in Pediatric Multiple Sclerosis Detection

(2019) MDAI 2019: Modeling Decisions for Artificial Intelligence, 4-6/09/2019
Nicoletta Nuzziello, Laura Vilardo, Paride Pelucchi, Arianna Consiglio, Sabino Liuni, Maria Trojano and Maria Liguori

Investigating the Role of MicroRNA and Transcription Factor Co-regulatory Networks in Multiple Sclerosis Pathogenesis

(2019) in Top 5 Contributions in Molecular Sciences: 2nd Edition, 2019
Nuzziello N, Ciaccia L and Liguori M.

Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs' World.

(2019) in Cells
Nicoletta Nuzziello and Maria Liguori

The MicroRNA Centrism in the Orchestration of Neuroinflammation in Neurodegenerative Diseases.

(2019) in Cells
Maria Liguori,1,* Nicoletta Nuzziello,1,+ Alessandro Introna,2,+ Arianna Consiglio,1 Flavio Licciulli,1 Eustachio D'Errico,2 Antonio Scarafino,2 Eugenio Distaso,2 and Isabella L. Simone2

Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis

(2018) in Frontiers in molecular neuroscience
Liguori M1, Nuzziello N1,2, Licciulli F1, Consiglio A1, Simone M2, Viterbo RG2, Creanza TM3, Ancona N3, Tortorella C2,4, Margari L2, Grillo G1, Giordano P5, Liuni S1, Trojano M2.

Combined microRNA and mRNA expression analysis in pediatric multiple sclerosis: an integrated approach to uncover novel pathogenic mechanisms of the disease.

(2018) in Human molecular genetics (Print)
Visualize all the publications (since 2016)